Stéphanie B ONNEAU Vice-presidente Personnels Sorbonne Université

Biophysicist, PhD, HDR Current position and interests Since 2005 : Associate Professor in Physics, Sorbonne Université (Pierre & Marie Curie). Laboratoire Jean Perrin – CNRS UMR 8237 Campus Pierre et Marie Curie (UPMC) – case courrier 114 4, place Jussieu – 75005 Paris Tel. : +33(0)1 44 27 90 64 Fax : +33(0) 1 69 87 43 60

Email. : [email protected] Web : http ://www.labos.upmc.fr/ljp/ ?people10

Research themes I Biophysics and photo-perturbation of biological and biomimetic membranes. I am interested in understanding the kinetics and nonequilibrium thermodynamics of biological systems. In this framework, I work on the characterization of the physical and biophysical parameters governing the properties of membranes, in relation to their ability to fulfill their biological functions. My main research themes are : — Photo-disruption and permeabilization of membrane systems, — Photo-control of mitochondrial stress and super-resolution imaging, — Photo-control of intracellular traffic and vectorization.

Research experiences and education Nov. 2013

H.D.R. (habilitation thesis) in Physics and in Biology, Univ. Paris 6. Biophysics and photo-perturbation of biological and biomimetic membranes.

2003 – 2005

Assistant Professor, Univ. Paris 5. New physical techniques to study axonal transport and mechanical properties of astrocytes.

2000 – 2003

PhD. student in biophysics, sup. D. Brault, Univ. Paris 6. Dynamics of tetrapyrrole interaction with lipoproteins and membranes : consequences on cell localization.

1999 – 2000 1998 – 1999

Master (DEA) in Biophysics, Paris 6. Master degree in Biology, Toulouse 3.

Communications scientifiques Number of research articles : 25 Proceedings : 6 Congresses : 31 Invited conferences : 7 h-index 17.

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Research responsabilities Team and staff Biomembrane team of the Laboratoire Jean Perrin. Awards and grants Dyn@mit (Emergence SU, 2017-...) – MITOMIM (DIM Nano-K IDF, 2013-17) – UE-FP7 "CELIM" (with Safarik University, Slovakia, 2013-2016) – PDTNat (FAPESP, with UNICAMP, Brazil, 2012-15) – COPOPDT (ANR P3N, 2010-2014 – 4 PID-CNRS EPOV and OPV (200811) – Hubert Curien Partnership "AURORA", EGIDE (with the Radium Institut, Norway, 2007), RETINA-France award (2004) – ARC PhD. fellowship (2000-2003). Reviewer Langmuir, Biochimica et Biophysica Acta – Biomembranes, Photochemical and Photobiological Sciences, JACS, International Journal of Pharmaceutics, Biophysical Journal. . . Research life and policy — Member of the steering group of the projects CONVERGENCE of the Pierre & Marie Curie University (2010-12). — Congresses and workshops organization. — Founder and moderator of the mailing list "Interfaces du vivant" of the University. — Jury of 12 PhD. theses (5 reviewers) and many recruitment jury of researcher (full or temporary assistants).

Teaching, mentoring and supervision Supervision : 5 PhD. and 6 masters, 10 Bachelor level internships. Teaching : Teaching in bachelor’s and master’s degrees, thermodynamics, biophysics and the interface between physics and biology.

Scholarly and Professional Academic Responsabilities 2018–...

Vice-Chancellor (Vice-president ) "Personnel, égalité professionelle et diversité" of Sorbonne Université,

2018–...

Elected member of the Conseil de la faculté des Sciences et Ingénierie

2015–...

Head of the programme of master of engineering in Physics.

Past responsabilities 2009–2018

Elected member of the Conseil de l’UFR (Physics department), Elected member of the Conseil scientifique de l’UFR de Physique (2009-13 and 2018).

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2010–2018 2013–2016 2011–2015 2005–2010

Master of Fundamental Physics and Applications : Directrice des études, head of the first year programme. External member, C.A. of the Muséum National d’Histoire Naturelle. Appointed to the Conseil National des Universités, section 28. Bachelor of physics : Co-lead of the second year of the programm "Physics and Interfaces".

Selected papers 1. Stéphanie Bonneau, Patrice Morlière and Daniel Brault. Dynamics of interactions of photosensitizers with lipoproteins and membrane-models : correlation with cellular incorporation and subcellular distribution. B IOCHEMICAL P HARMACOLOGY, 2004, 68(7) :1443-52. (IF 5.091). 2. Halina Mojzisova, Stéphanie Bonneau, Philippe Maillard, Kristian Berg, Daniel Brault. Photosensitizing properties of chlorins in solution and in membrane mimicking systems : The role of the photosensitizer localization within the lipidic bilayer. P HOTOCHEMICAL & P HOTOBIOLOGICAL S CIENCES, 2009, 8(6) :778-87. (IF 2.235). 3. Julien Heuvingh, Stéphanie Bonneau. Asymmetric Oxidation of Giant Vesicles triggers Curvature-associated Shape Transition and Permeabilization. B IOPHYSICAL J OURNAL, 2009, 97(11) : 2904-2912. (IF 3.632). 4. Elyes Mabrouk, Stéphanie Bonneau, Ling Jia, Damien Cuvelier, Min-Hui Li, Pierre Nassoy. Photosensitization of polymer vesicles : a multistep chemical process deciphered by micropipette manipulation. S OFT M ATTER, 2010, 6(19) :4863-75. (IF 3.798). 5. Rachid Kerdous, Julien Heuvingh, Stéphanie Bonneau. Photo-dynamic induction of oxidative stress within cholesterol-containing membranes : Shape transitions and permeabilization. B IOCHIMICA ET B IOPHYSICA ACTA - B IO MEMBRANES , 2011, 1808 (12) :2965-2972. (IF 3.687). 6. Amanda K. A. Silva, Jelena Kolosnjaj-Tabi, Stephanie Bonneau, Iris Marangon, Nicole Boggetto, Kelly Aubertin, Olivier Clément, Michel Francis Bureau, Nathalie Luciani, Florence Gazeau, Claire Wilhelm. Magnetic and Photoresponsive Theranosomes : Translating Cell-Released Vesicles into Smart Nanovectors for Cancer Therapy. ACS N ANO, 2013, 7(6) :4954–4966. (IF 13.334). 7. Amanda K. A. Silva, Nathalie Luciani, Florence Gazeau, Kelly Aubertin, Stephanie Bonneau, Cédric Chauvierre, Didier Letourneur, Claire Wilhelm. Cell microvesicles for magnetic drug targeting. N ANOMEDICINE : N ANOTECHNO LOGY, B IOLOGY AND M EDICINE , march 2015, 11(3) :645-655. (IF 5.671). 8. Víctor G. Almendro-Vedia, Paolo Natale, Michael Mell, Stéphanie Bonneau, Francisco Monroy, Frederic Joubert and Iván López-Montero. Nonequilibrium fluctuations of lipid membranes by the rotating motor protein F1F0 ATP synthase. PNAS, Oct. 2017, 114(43) :11291–11296. (IF 9.661).

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