Meeting Two days with GPCRs in Montpellier June 12-13,2008 *La Grande Motte* “Structure-function relationships of G-Protein Coupled

Receptors in the spotlight”

THURSDAY June 12

-PRELIMINARY PROGRAM-

8h30-ARRIVAL AND CHECK IN WITH COFFEE AND CROISSANTS 9h00-WELCOME AND INTRODUCTION BY Joel BOCKAERT GPCRs: Quo Vadis? 9h30-Session 1: STRUCTURE AND ACTIVATION MECHANISMS 9h30-OPENING CONFERENCE by Gebhard F.X SCHERTLER University of Cambridge, UK)

(MRC,

Structure of the human beta 2 adrenergic receptor in complex with an antibody fragment: Progress in obtaining recombinant G protein Coupled Receptor structures by high brilliance micro crystallography 10h20-Nicolas FLOQUET (Institut des Biomolécules Max Mousseron, Montpellier, France) Modelling and Structure-activity relationships of the human Ghrelin receptor (GHSR-1a) 10h40-to be selected from external proposals 11h00-COFFEE BREAK 11h20-Aline MOULIN (Institut des Biomolécules Max Mousseron, Montpellier, France) From peptide to non-peptide for the development of ghrelin receptor ligands 11h40-Marjorie DAMIAN (Institut des Biomolécules Max Mousseron, Montpellier, France) Molecular bases of GPCR:arrestin interactions

12h00-Philippe RONDARD (IGF, Dep of Molecular Pharmacology, Montpellier, France) Functioning of the dimeric GABAB receptor VFTs: insights from a Glycan wedge approach 12h20-to be selected from external proposals 12h40-LUNCH 14h00-POSTERS 15h30-Session 2: OLIGOMERIZATION AND CROSS-TALKING 15h30-OPENING CONFERENCE by Oliver ERNST (Institute of Medical Physics and Biophysics, Berlin, Germany) Activation and quaternary structure of rhodopsin 16h20-Thierry DURROUX (IGF,Dep of Molecular Pharmacology,Montpellier, France) Evidence for the existence of G protein-coupled receptor oligomers in native tissues 16h40-Lucie PELLISSIER (IGF, Dep of Neurobiology, Montpellier, France) Functionning of a class A GPCR dimer: use of a 5-HT4 receptor activated solely by synthetic ligands 17h00-to be selected from external proposals 17h20-COFFEE BREAK 17h40-Julie PERROY (IGF, Dep of Neurobiology, Montpellier, France) GPCR interaction with ionotropic receptors: mGluR5 and NMDA receptor complexes 18h00-Pierre CORBEAU (IGH, Montpellier, France) CCR5 as an HIV coreceptor: expression, functions and partners 18h20-to be selected from external proposals 18h40-DISCUSSION AROUND POSTERS WITH APPETIZERS 20h30-DINNER 22h00-EVENING PARTY (Free discussion around the bar and under the moonlight with access to posters)

FRIDAY June 13 9h00-9h30: INTRODUCTION BY Jean Martinez (IBMM, Montpellier) 9h30-SESSION 3: SIGNALING AND MOLECULAR COMPLEXES 9h30-OPENING CONFERENCE by Ralf JOCKERS (Institut Cochin, Paris, France) Regulation of G protein-coupled receptor signaling by associated protein complexes 10h20-Julie PENNEQUIN (IGF, Dep of Oncologie, Montpellier, France) Regulation of Wnt and Notch signalling pathways by Progastrine in colon cancer. 10h40-Marilyne LABASQUE (IGF, Dep of Neurobiology, Montpellier, France) Physical interaction of calmodulin with the 5-HT2C receptor is essential for G protein-independent, arrestin-dependent, receptor signalling. 11h00-to be selected from external proposals 11h20-COFFEE BREAK 11h40-Federica BERTASO (IGF, Dep of Neurobiology, Montpellier, France) Role of scaffolding proteins in metabotropic/ionotropic glutamate receptor crosstalk. 12h00-Nicolas DELCOURT (IGF, Dep of Neurobiology & Sanofi-Aventis, Labège, France) IGF-1 highjacks PACAP type 1 GPCR to protect neurons against apoptosis. 12h20-to be selected from external proposals 12h40-LUNCH WITH ACCESS TO POSTERS 14h00-SESSION 4: BIOPHYSICAL METHODS FOR CELLULAR DYNAMIC STUDIES 14h00-OPENING CONFERENCE by Akihoro KUSUMI (Institut of Medical Sciences, Kyoto, Japan)

14h50-Sebastien GRANIER (IGF, Dep of Molecular Pharmacology, Montpellier, France) Structure and conformational changes in the C-terminal domain of the beta2adrenoceptor: insights from fluorescence resonance energy transfer studies 15h10-Cedric ESPENEL (Centre de Biochimie Structurale, Montpellier, France) The tetraspanin web: a new level of complexity of lateral membraneheterogeneity revisited with single molecule analysis 15h30-to be selected from external proposals 15h50-COFFEE BREAK 16h10-Laetitia COMPS-AGRAR (IGF, Dep of Molecular Pharmacology, Montpellier, France) Cell surface protein-protein interaction analysis with combined time-resolved FRET and snap-tag technologies: application to GPCR oligomerization 16h30-Pierre-Emmanuel MILHIET (Centre de Biochimie Structurale, Montpellier, France) High resolution imaging of membrane proteins by Atomic Force Microscopy 16h50-to be selected from external proposals 17h10: GPCR TARGETS fOR PHARMACEUTICAL INDUSTRY Montpellier, France)

NEW DRUG DICOVERY IN THE by Pierre CASELLAS (Sanofi-Aventis,

17h50: ROUND TABLE AND CONCLUSION 18h30: DEPARTURE