Lionel Velly MCU-PH, PhD Aix-Marseille University, France

Quantitative DTI An application to Anoxic or Traumatic brain injury

Lionel Velly MCU-PH, PhD Anaesthesiologist-Neurointensivist Aix-Marseille University, France

Quantitative DTI Fractional Anisotropy

Low FA

High FA

(isotropic)

(anisotropic)

Figures supplémentaires Figures supplémentaires ! CARDIAC&ARREST&&&DTI& ! T2"FLAIR"

T2"FLAIR"

CARDIAC&ARREST&&&DTI& T2"FLAIR"

T2"FLAIR"

Frac*onal"Anisotropy"(FA)" Frac*onal"Anisotropy"(FA)" Frac*onal"Anisotropy"(FA)" Frac*onal"Anisotropy"(FA)"

0" 0"

CPC"2" 0.5" Highanisotropy"

CPC"5"

CPC"2" 0.5" Highanisotropy"

0" Low"anisotropy"

CPC"5" 0" Low"anisotropy"

Quantitative DTI Fractional Anisotropy

Traumatic Brain Injury PATIENT$1$ Figures T2*$ supplémentaires !

PATIENT$2$ FLAIR$

T2*$

FLAIR$

CARDIAC&ARREST&&&DTI& T2"FLAIR"

Frac*onal"Anisotropy"(FA)"

T2"FLAIR"

Frac*onal"Anisotropy"(FA)"

0"

CPC"2" 0.5" Highanisotropy"

CPC"5" 0" Low"anisotropy"

Quantitative DTI FA%measurement%% First ..Then …

COMASOFT : 20 ROI in White Matter

(FA/MD/λ1/λT)

Quantitative DTI FA%measurement%% First ..Then …

COMASOFT : 20 ROI in White Matter

(FA/MD/λ1/λT)

Quantitative DTI FA%measurement%% %TRANSFORMATION%IN%MNI%SPACE%

COMASOFT%

Subject$Space$

MNI$Space$

FA$

T1$ $co0.001 FA decrease

P0.001 FA decrease

P0.001 FA decrease

P