Mercredi 26 Mars

Groupe Français des Peptides et des Protéines

12h00 12h30 13h45

Les Géants de Lille

PHINAERT

&

LYDERIC

vous invitent à un colloque

Chemical ligation methods allow the site-specific coupling of unprotected biomolecules, and thus the convergent synthesis of complex molecular architectures made of peptides, oligosaccharides or nucleic acids. The goal of this conference is to present the state-of-the-art research in this field. Two key lecturers, Antonello Pessi and Philip Dawson, will present their recent achievements. The conference is open to oral and poster presentations.

14h00- Application of chemoselective ligation to peptide and protein engineering A. Pessi, Istituto di Ricerche di Biologia Molecolare and Merck Research Laboratories, Pomezia, Italy

It is organized at the Institut de Biologie de LILLE, situated on Pasteur Institute of LILLE campus.

17h20- Furan oxidation as a novel strategy for cross-linking and labelling of biomolecules A. Madder, Laboratory for Organic and Biomimetic Chemistry, Gent, Belgium

Access : -10-15 min by foot from Lille Flandre or Lille Europe train stations -accessible by underground (Lille Grand Palais station).

17h40-Use of Chemoselective Oxime Ligation for Conjugation of Oligonucleotides E. Defrancq, Département de Chimie Moléculaire, UJF, Grenoble, France

Plan : http://www.ibl.fr/spip.php?article20 Hotels : http://www.ibl.fr/spip.php?article27

PHINAERTLYDERIC Mercredi 26 et Jeudi 27 Mars 2008 Institut de Biologie de LILLE (59) 1 rue du Professeur Calmette FRANCE Contacts :

[email protected] [email protected]

Welcome Regional Lunch Opening

For more details on : -our Institute : http://www.ibl.fr -our Research team : http://www.ibl.fr/spip.php?article29

Information, registration and abstract model of communication in Word format can be found at : http://gfpp.free.fr

15h00- Triazole multi-ligation : a new tool for the production of backboneengineered proteins V. Aucagne, Centre de Biophysique Moléculaire, Orléans, France 15h20- A new photolabile carboxyl protecting group for native chemical ligation B. Briand, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany 15h40- Design of Amyloïd fibril models and inhibitors of fibrillogenesis M. Ouberai, Département de Chimie Moléculaire, UJF, Grenoble, France 16h00-

18h30-

Coffee break and posters

Aperitif

Jeudi 27 Mars 09h00- Oxime ligation for the total synthesis of multi-functional glycoproteins of branched architecture A. Delmas, Centre de Biophysique Moléculaire, Orléans, France 09h20- Chemoselective Ligations onto Multivalent Scaffolds and Biosensor Surfaces E. Lempens, Eindhoven University of Technology, Eindhoven, The Netherlands 09h40- Functional proteomics strategy for trafficking pathway analysis R. Christiano, Institut Curie, Paris, France 10h00- All-On-Resin Syntheses and Biological Assays of RGD-containing Peptides D. Boturyn, Département de Chimie Moléculaire, UJF, Grenoble, France 10h2010h30-

Announcements Coffee break and posters

11h00- Chemical ligation : the art of performing synthetic organic chemistry in water without protecting groups P. Dawson, Scripps Research Institute, La Jolla, California 12h0012h10-

Closure Lunch