Université de Sherbrooke Department of pharmacology-physiology 3001, 12è Avenue Nord Sherbrooke, Québec J1H 5N4 Canada

[email protected] Phone: +1 (819) 821-8000 ext. 70109 Mobile: +1 (819) 823-2632 Fax: +1 (819) 564-5400 Personal webpage

Élie Besserer-Offroy, BMSc, PhD Candidate Education Oct 2010 – present

Université de Sherbrooke Philosophiæ Doctor (Ph.D.) Pharmacology Sherbrooke, Canada

Sep 2009 – Jun 2010

Université Claude Bernard Lyon 1 Bachelor of Medical Sciences (B.M.Sc.) Medical Biochemistry Villeurbanne, France

Sep 2007 – Jun 2009

Université de Franche-Comté Diploma of general university studies (DEUG) Cell Biology, Physiology & Biochemistry Besançon, France

Research Experience May 2012 – present

Ph.D. Candidate Université de Sherbrooke, Department of pharmacology-physiology Sherbrooke, Canada Deciphering the signaling of Neurotensin Receptors 1 and 2 leading to analgesia by characterizing the molecular signature of differents NT receptors ligands with specific physiological effects. Advisors: Richard Leduc, Ph.D. and Philippe Sarret, Ph.D.

Oct 2010 – May 2012

M.Sc. Candidate (direct transition M.Sc. – Ph.D.) Université de Sherbrooke, Department of pharmacology Sherbrooke, Canada BRET-Based assay development for high throughput screening (HTS) of a peptidomimetic library on Neurotensin Receptor 1 and Apelin Receptor in collaboration with Tranzyme Pharma Inc. and the IRIC HTS Core Facility at the Université de Montréal. Advisors: Richard Leduc, Ph.D. ; Éric Marsault, Ph.D. and Philippe Sarret, Ph.D.

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Élie Besserer-Offroy – Curriculum Vitae Apr 2010 – Oct 2010

2016-03-24

Research Intern Centre national de la recherche scientifique, Institut de Biologie et Chimie des Protéines Lyon, France Study of the interaction between the third extra-cellular loop of ABCG2 (entire purified protein) and the Human Serum Albumin (HSA) for the transfer of rejected porphyrins. Advisors: Élodie Dézusinges, Pharm.D., Ph.D. and Pierre Falson, Ph.D.

Other Experience Jan 2015 – present

Member of the Board of Directors and Treasurer Quebec Network of Junior Pain Ivestigators (QNJPI)

Dec 2013 – present

Program Committee Member - Ph.D. Students representative Graduate programs in pharmacology Université de Sherbrooke, Department of pharmacology-physiology Sherbrooke, Canada

Oct 2013 – present

Member of the Student Committee Sherbrooke Institute of Pharmacology (IPS) Sherbrooke, Canada

Dec 2013 – Feb 2015

Director of Communications Association of graduate students in pharmacology from the Université de Sherbrooke – RECPUS Sherbrooke, Canada

Dec 2013 – Dec 2014

Assistant Director of Communications Journée Phare 2014 Sherbrooke, Canada Journée Phare is a provincial-scale event highlighting the quality of pharmacology research and promoting collaboration among people. The main goal of Journée Phare is to gather students, research assistants and researchers from academy and industry in order to discuss about pharmacology.

Dec 2012 – Dec 2013

Chair of the organizing committee Journée Phare 2013 Sherbrooke, Canada

Dec 2012 – Dec 2013

Executive Vice-President Association of graduate students in pharmacology from the Université de Sherbrooke – RECPUS Sherbrooke, Canada RECPUS is the association of all graduate students from the Sherbrooke Institute of Pharmacology (IPS). As Vice-President I was in charge of the relation between graduate students and the Faculty, Department and Institute management.

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Professional development Present March 2016

Project Management Professional Course, ITU Online Intellectual property law and policy – Patents

May 2015

Design and Interpretation of Clinical Trials, Online course by John Hopkins University – Bloomberg School of Public Health

April 2015

Clinical Terminology, Online course by University of Pittsburgh- School of Nursing

April 2015

ABC of project management, Online course by École centrale de Lille (France)

April 2015

Six Sigma Yellow Belt Professional, Online course by 6sigma study, April 2015

April 2015

Scrum Fundamentals (SFC), Online course by Scrum study

November 2014

Cell Culture Basics Certification, Online course by Gibco

December 2012

University teaching course, EPU940, Universté de Sherbrooke

Awards & Grants January 2016 September 2015

Research Grant for a pilot study from Sherbrooke Neuroscience Centre ($7,500) Travel Grant from Québec Pain Research Network ($1,000) - Declined

May 2015

Dean’s honor list (for being in the top 10% of graduate students)

May 2014

IPS/CNS Scholarship ($15,000; 1year for salary support)

April 2014

Sherbrooke Centre of Excellence in Neurosciences Scholarship ($10,000; 1year for salary support)

June 2013

Travel Grant from Sherbrooke Neurosciences Centre ($500)

June 2013

Travel Grant from Québec Pain Research Network ($1,000)

April 2012

Domenico Regoli Scholarship ($19,000; 1year for salary support)

April 2011

IPS/CREPSUS Scholarship ($15,000; 1year for salary support)

Skills & Activities Skills

Languages Scientific Memberships

Pharmacology, GPCR Signaling, Cell Based Assays, High Throughput Screening, Cell-based Biosensors, Radioligand Binding, Fluorescence, Bioluminescence Resonance Energy Transfer (BRET), Drug Discovery, Project Management, Troubleshooting, Medical Biochemistry, Biotechnology, Recombinant Proteins Production & Purification French (Native proficiency) English (Full bilingual proficiency) American Society for Clinical Pathology American Peptide Society Society for Neurosciences 3

Élie Besserer-Offroy – Curriculum Vitae

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Royal Society of Biology (UK), Member - MRSB Interests

Ski, Bicycle, Scuba diving

References Prof. Philippe Sarret, Ph.D. Director, Neurosciences Centre Université de Sherbrooke 3001, 12è Avenue Nord Sherbrooke, Qc J1H 5N4 Canada

Prof. Richard Leduc, Ph.D. Pharmacology-physiology Université de Sherbrooke 3001, 12è Avenue Nord Sherbrooke, Qc J1H 5N4 Canada

Prof. Éric Marsault, Ph.D. Pharmacology-physiology Université de Sherbrooke 3001, 12è Avenue Nord Sherbrooke, Qc J1H 5N4 Canada

Tel: +1 (819) 821-8000 ext. 72554 [email protected]

Tel: +1 (819) 821-8000 ext. 75413 [email protected]

Tel: +1 (819) 821-8000 ext. 72433 [email protected]

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Publications Journal Publications (* these authors contributed equally to the work) Alexandre Murza, Xavier Sainsily, David Coquerel, Jérôme Côté, Patricia Marx, Élie Besserer-Offroy, Jean-Michel Longpré, Jean Lainé, Dany Salvail, Robert Dumaine, Richard Leduc, Olivier Lesur, Mannix Auger-Messier, Philippe Sarret, Éric Marsault: Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Mar; just accepted manuscript. doi: 10.1021/acs.jmedchem.5b01549 Denisa Hapău, Emmanuelle Rémond, Roberto Fanelli, Mélanie Vivancos, Adeline René, Jérôme Côté, Élie Besserer-Offroy, Jean-Michel Longpré, Jean Martinez, Valentin Zaharia, Philippe Sarret, Florine Cavelier: Stereoselective Synthesis of β -(5-Arylthiazolyl) α -Amino Acids and Use in Neurotensin Analogues. Eur J Org Chem. 2016 Jan. 2016(5):1017-24. doi: 10.1002/ejoc.201501495 *Élie Besserer-Offroy, *Roberto Fanelli, Adeline René, Jérôme Côté, Pascal Tétreault, Jasmin ColeretteTremblay, Jean-Michel Longpré, Richard Leduc, Jean Martinez, Philippe Sarret, Florine Cavelier: Synthesis and Characterization in Vitro and in Vivo of (L)-(Trimethylsilyl)alanine Containing Neurotensin Analogues. J Med Chem. 2015 Oct; 58(19):7785-95. doi: 10.1021/acs.jmedchem.5b00841 Alexandre Murza, Élie Besserer-Offroy, Jérôme Côté, Patrick Bérubé, Jean-Michel Longpré, Robert Dumaine, Olivier Lesur, Mannix Auger-Messier, Richard Leduc, Philippe Sarret, Éric Marsault: CTerminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action. J Med Chem. 2015 Mar; 58(5):2431-40. doi: 10.1021/jm501916k Michel Demeule, Nicolas Beaudet, Anthony Régina, Élie Besserer-Offroy, Pascal Tétreault, Karine Belleville, Christian Ché, Alain Larocque, Caroline Thiot, Richard Béliveau, Jean-Michel Longpré, Richard Leduc, Jean E. Lachowicz, Steven L. Gonias, Jean-Paul Castaigne, Philippe Sarret: Creation of a brain-penetrant peptide-neurotensin conjugate with antinociceptive properties. J Clin Invest. 2014 Mar; 124(3):1199-213. doi: 10.1172/JCI70647 Alexandre Murza, Alexandre Parent, Élie Besserer-Offroy, Hugo Tremblay, Félix Karadereye, Nicolas Beaudet, Richard Leduc, Philippe Sarret, Éric Marsault: Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability. ChemMedChem 2012 Feb; 7(2):318-25. doi: 10.1002/cmdc.201100492

Conference Proceedings Christine Mona, Marilou Lefrançois, Philip E. Boulais, Élie Besserer-Offroy, Richard Leduc, Nikolaus Heveker, Éric Marsault, Emanuel Escher: Synthetic Agonists for the CXCR4 Receptor: SAR, Signaling Pathways and Peptidomimetic Transition. 23rd American Peptide Symposium (Peptides Across the Pacific), Waikoloa, Hawai'I, USA; 06/2013 doi: 10.17952/23aps.2013.198 Alexandre Murza, Alexandre Parent, Élie Besserer-Offroy, Nicolas Beaudet, Philippe Sarret, Éric Marsault: Elucidation of the structure-activity relationships of Apelin: Influence of unnatural amino acids on binding, signaling and plasma stability. 32nd European Peptide Symposium, Athens, Greece; 09/2012

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Oral presentations Élie Besserer-Offroy, Jérôme Côté, Patrick Bérubé, Jean-Michel Longpré, Richard Leduc, Éric Marsault, Philippe Sarret: New biased analogs of Apelin-13 and their impacts on cardiovascular effects. 5è rencontres Montpellier – Sherbrooke; June 11 , 2015; Sherbrooke, Canada th

Élie Besserer-Offroy, Andrea Brumwell, Jean-Michel Longpré, Philippe Sarret, Richard Leduc: Molecular Signature of the Neurotensin Receptor 1. 3è Journée Scientifique du RQRM; September 18 -19 , 2013; Montreal, Canada th

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Élie Besserer-Offroy, Jean-Michel Longpré, Dominic Devost, Billy Breton, Christian Le Gouil, Michel Bouvier, Éric Marsault, Philippe Sarret, Richard Leduc: BRET-Based Assay Development for the Discovery of Novel GPCR Ligands. Journée Phare 2012; November 16 , 2012; Orford, Canada th

Élie Besserer-Offroy, Éric Marsault, Philippe Sarret, Richard Leduc: BRET-Based Assay Development for the Discovery of Novel GPCR Ligands. Conference of the Sherbrooke Institute of Pharmacology; October 25 , 2012; Sherbrooke, Canada th

Poster presentations (* denotes presenting author) *Élie Besserer-Offroy, Mylène Lafrance, Mona Ouirzane, Alexandre Murza, Jean-Michel Longpré, Éric Marsault, Richard Leduc, Philippe Sarret: β-arrestin-2-biased apelin receptor agonists as novel potent analgesics. McGill Pain Day 2016 (20 Anniversary); January 21st, 2016; Montréal, Canada th

*Mélanie Vivancos, Élie Besserer-Offroy, Rébecca Brouillette, Adeline René, Roberto Fanelli, Mylène Lafrance, Pascal Tétreault, Jasmin Collerette-Tremblay, Jean-Michel Longpré, Jean Martinez, Florine Cavelier, Philippe Sarret: Site-selective modifications of the neurotensin hexapeptide fragment lead to the generation of highly active and metabolically stable NT(8-13) analogs. McGill Pain Day 2016 (20 Anniversary); January 21st, 2016; Montréal, Canada th

*Élie Besserer-Offroy, Mylène Lafrance, Mona Ouirzane, Alexandre Murza, Jean-Michel Longpré, Éric Marsault, Richard Leduc, Philippe Sarret: β-arrestin-2-biased apelin receptor agonists as novel potent analgesics. Journée Phare 2015; November 19 -20 , 2015; Orford, Canada th

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*Mélanie Vivancos, Élie Besserer-Offroy, Rébecca Brouillette, Adeline René, Roberto Fanelli, Mylène Lafrance, Pascal Tétreault, Jasmin Collerette-Tremblay, Jean-Michel Longpré, Jean Martinez, Florine Cavelier, Philippe Sarret: Site-selective modifications of the neurotensin hexapeptide fragment lead to the generation of highly active and metabolically stable NT(8-13) analogs. Journée Phare 2015; November 19 20 , 2015; Orford, Canada th

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*Rebecca Brouillette, Christine Mona, Élie Besserer-Offroy, Sandrine Lavenus, Jérôme Côté, Marc Sousbie, Jean-Michel Longpré, Emanuel Escher, Richard Leduc, Michel Grandbois, Éric Marsault, Philippe Sarret: Profiling the cellular and physiological effects of pepducins targeting the first intracellular loop of neurotensin receptor 1 (NTS1). Journée Phare 2015; November 19 -20 , 2015; Orford, Canada th

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*Sandrine Lavenus, Élie Besserer-Offroy, Élie Simard, Richard Leduc, Michel Grandbois: In depth profiling of AT1 signaling using cell-based and label free surface plasmon resonance: major implication of Gqindependent pathways in cell response. Journée Phare 2015; November 19 -20 , 2015; Orford, Canada th

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*Marc Sousbie, Élie Besserer-Offroy, Jean-Michel Longpré, Philippe Sarret, Richard Leduc, Éric Marsault: Macrocyclic analogues of Neurotensin 8-13 : effect of conformational restriction on ligand binding and signalling. Journée Phare 2015; November 19 -20 , 2015; Orford, Canada th

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*Sandrine Lavenus, Élie Besserer-Offroy, Élie Simard, Richard Leduc, Michel Grandbois: In depth profiling of AT1 signaling using cell-based and label free surface plasmon resonance: major implication of Gqindependent pathways in cell response. 16 Annual Joint Meeting of the Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec; October 22 -24 , 2015; Orangeville, Canada th

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*Marc Sousbie, Élie Besserer-Offroy, Jean-Michel Longpré, Philippe Sarret, Richard Leduc, Éric Marsault: Macrocyclic analogues of Neurotensin 8-13 : effect of conformational restriction on ligand binding and signalling. 16 Annual Joint Meeting of the Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec; October 22 -24 , 2015; Orangeville, Canada th

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*Élie Besserer-Offroy, Mylène Lafrance, Mona Ouirzane, Alexandre Murza, Jean-Michel Longpré, Éric Marsault, Richard Leduc, Philippe Sarret: β-arrestin-2-biased apelin receptor agonists as novel potent analgesics. Neurosciences 2015 (45 annual meeting of the Society for Neuroscience) October 17 -21 , 2015; Chicago, IL, USA th

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*Mélanie Vivancos, Élie Besserer-Offroy, Rébecca Brouillette, Adeline René, Roberto Fanelli, Mylène Lafrance, Pascal Tétreault, Jasmin Collerette-Tremblay, Jean-Michel Longpré, Jean Martinez, Florine Cavelier, Philippe Sarret: Site-selective modifications of the neurotensin hexapeptide fragment lead to the generation of highly active and metabolically stable NT(8-13) analogs. Neurosciences 2015 (45 annual meeting of the Society for Neuroscience) October 17 -21 , 2015; Chicago, IL, USA th

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*Marc Sousbie, Élie Besserer-Offroy, Jean-Michel Longpré, Philippe Sarret, Richard Leduc, Éric Marsault: Macrocyclic analogues of Neurotensin 8-13 : effect of conformational restriction on ligand binding and signalling. 24 American Peptide Symposium; June 20 -25 , 2015; Orlando, FL, USA th

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*Christine Mona, Marilou Lefrançois, Élie Besserer-Offroy, Richard Leduc, Nikolaus Heveker, Éric Marsault, Emanuel Escher: CXCR4-induced chemotaxis is not β -arrestin mediated, evidence from synthetic CXCR4 agonists. 24 American Peptide Symposium; June 20 -25 , 2015; Orlando, FL, USA th

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*Marc Sousbie, Élie Besserer-Offroy, Jean-Michel Longpré, Philippe Sarret, Richard Leduc, Éric Marsault: Macrocyclic analogues of Neurotensin 8-13 : effect of conformational restriction on ligand binding and signalling. 98 Canadian Chemistry Conference and Exhibition; June 13 -17 , 2015; Ottawa, Canada th

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Jasmin Colerette-Tremblay, *Élie Besserer-Offroy, Jérôme Côté, Pascal Tétreault, Adeline René, JeanMichel Longpré, Richard Leduc, Jean Martinez, Florine Cavelier, Philippe Sarret: Characterization of novel neurotensin analogs with TMSAla residue. McGill Pain Day 2015; January 22 , 2015; Montréal, Canada nd

*Sandrine Lavenus, Xavier Sainsily, Élie Simard, Élie Besserer-Offroy, Michel Grandbois, Richard Leduc: Profiling of AT1 and UII signaling using surface plasmon resonance as a cell-based label free approach. Journée Phare 2014; November 13 -14 , 2014; Orford, Canada th

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*Alexandre Murza, Élie Besserer-Offroy, Patrick Bérubé, Jean-Michel Longpré, Philippe Sarret, Éric Marsault: Design, synthesis and exploration of structure-function relationship studies of new macrocyclic derivatives of apelin-13. Journée Phare 2014; November 13 -14 , 2014; Orford, Canada th

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*Rebecca Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Philippe Sarret: Characterizing the signaling pathways activated by the receptor NTS1 in response to NT analogs involved in hypothermia, hypotension, and analgesia. Journée Phare 2014; November 13 -14 , 2014; Orford, Canada th

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*Jasmin Colerette-Tremblay, Élie Besserer-Offroy, Jérôme Côté, Adeline René, Jean-Michel Longpré, Jean Martinez, Florine Cavelier, Philippe Sarret: Novel neurotensin analogs with TMSAla residue induce antinociception without hypothermia. Journée Phare 2014; November 13 -14 , 2014; Orford, Canada th

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*Marc Sousbie, Élie Besserer-Offroy, Philippe Sarret, Richard Leduc, Éric Marsault: Analogues macrocycliques de la neurotensine 8-13 : Effets de la restriction conformationnelle du ligand sur la liaison et la signalisation. Journée Phare 2014; November 13 -14 , 2014; Orford, Canada th

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Pascal Tétreault, Élie Besserer-Offroy, Alexandre Murza, *Alexandre Parent, Patrick Bérubé, Adeline René, Isabelle Dubuc, Jean-Michel Longpré, Nicolas Beaudet, Richard Leduc, Éric Marsault, Jean Martinez, Florine Cavelier, Philippe Sarret: Analgesic potency of a new neurotensin analog in different experimental pain models. Journée Phare 2014; November 13 -14 , 2014; Orford, Canada th

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*Élie Besserer-Offroy, Andrea Brumwell, Alexandre Murza, Jean-Michel Longpré, Philippe Sarret, Richard Leduc: Establishing the signaling signature of hNTS1 engaged following endogenous neurotensinlike peptide stimulation. 15 Annual Joint Meeting of the Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec; October 2 -4 , 2014; Bromont, Canada th

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*Élie Besserer-Offroy, Alexandre Murza, Patrick Bérubé, Trang Dinh, Jean-Michel Longpré, Richard Leduc, Éric Marsault, Philippe Sarret: C-terminal modifications of Apelin-13: generation of new biased analogs and impact on hypotensive effect. 15 Annual Joint Meeting of the Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec; October 2 -4 , 2014; Bromont, Canada th

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*Alexandre Murza, Élie Besserer-Offroy, Patrick Bérubé, Jean-Michel Longpré, Philippe Sarret, Éric Marsault: Design, synthesis and exploration of structure-function relationship studies of new macrocyclic derivatives of apelin-13. 15 Annual Joint Meeting of the Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec; October 2 -4 , 2014; Bromont, Canada th

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Pascal Tétreault, Élie Besserer-Offroy, Alexandre Murza, *Alexandre Parent, Patrick Bérubé, Adeline René, Isabelle Dubuc, Jean-Michel Longpré, Nicolas Beaudet, Richard Leduc, Éric Marsault, Jean Martinez, Florine Cavelier, Philippe Sarret: Analgesic potency of a new neurotensin analog in different experimental pain models. 15 Annual Joint Meeting of the Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec; October 2 -4 , 2014; Bromont, Canada th

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*Sandrine Lavenus, Xavier Sainsily, Élie Simard, Élie Besserer-Offroy, Michel Grandbois, Richard Leduc: Profiling of AT1 and UII signaling using surface plasmon resonance as a cell-based label free approach. 15 Annual Joint Meeting of the Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec; October 2 -4 , 2014; Bromont, Canada th

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*Élie Besserer-Offroy, Alexandre Murza, Patrick Bérubé, Trang Dinh, Jean-Michel Longpré, Richard Leduc, Éric Marsault, Philippe Sarret: C-terminal modifications of Apelin-13: generation of new biased analogs and impact on hypotensive effect. 4 Colloque du Réseau Québécois de Recherche sur le Médicament (RQRM); September 22 -23 , 2014; Orford, Canada – Published abstract è

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*Alexandre Murza, Élie Besserer-Offroy, Patrick Bérubé, Jean-Michel Longpré, Philippe Sarret, Éric Marsault: Design, synthesis and exploration of structure-function relationship studies of new macrocyclic derivatives of apelin-13. 4 Colloque du Réseau Québécois de Recherche sur le Médicament (RQRM); September 22 -23 , 2014; Orford, Canada – Published abstract è

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*Rebecca Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Philippe Sarret: Characterizing the signaling pathways activated by the receptor NTS1 in response to NT analogs involved in hypothermia, hypotension, and analgesia. 10 Journée Scientifique de la FMSS (1 Cycle); September 12 , 2014; Sherbrooke, Canada è

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*Jasmin Colerette-Tremblay, Élie Besserer-Offroy, Jérôme Côté, Adeline René, Jean-Michel Longpré, Jean Martinez, Florine Cavelier, Philippe Sarret: Novel neurotensin analogs with TMSAla residue induce antinociception without hypothermia. 10 Journée Scientifique de la FMSS (1 Cycle); September 12 , 2014; Sherbrooke, Canada è

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Alexandre Murza, Élie Besserer-Offroy, Patrick Bérubé, Jean-Michel Longpré, Philippe Sarret, *Éric Marsault: Design, Synthesis and Structure-Activity Relationship Studies of New Macrocyclic Analogs of Apelin-13. 97 Canadian Chemistry Conference and Exhibition; June 1 -5 , 2014; Vancouver, Canada th

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*Alexandre Murza, Élie Besserer-Offroy, Mylène Lafrance, Trang Dinh, Jean-Michel Longpré, Richard Leduc, Éric Marsault, Philippe Sarret: Incorporation of unnatural amino acids into the C-terminal end of apelin-13: influence on binding, biased signaling and receptor functions. Journée Phare 2013; November 21 -22 , 2013; Orford, Canada st

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*Andrea Brumwell, Élie Besserer-Offroy, Jean-Michel Longpré, Philippe Sarret, Richard Leduc: Molecular Signature of the Neurotensin Receptor 1. Journée Phare 2013; November 21 -22 , 2013; Orford, Canada st

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*Trang Dinh, Élie Besserer-Offroy, Alexandre Murza, Jean-Michel Longpré, Philippe Sarret, Richard Leduc, Éric Marsault: Élucidation de la relation structure-activité de l’Apéline : Influence d’acides aminés non naturels sur la signalisation du récepteur APJ. Journée Phare 2013; November 21 -22 , 2013; Orford, Canada st

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*Élie Besserer-Offroy, Pascal Tétreault, Mylène Lafrance, Alexandre Murza, Adeline René, Jean-Michel Longpré, Florine Cavelier, Jean Martinez, Éric Marsault, Richard Leduc, Philippe Sarret: Deciphering the NTS1 receptor signalling pathways leading to analgesia and hypothermia. Neurosciences 2013 (43rd annual meeting of the Society for Neuroscience) November 9 -13 , 2013; San Diego, CA, USA th

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*Alexandre Murza, Élie Besserer-Offroy, Mylène Lafrance, Nicolas Beaudet, Jean-Michel Longpré, Richard Leduc, Éric Marsault, Philippe Sarret: Incorporation of unnatural amino acids into the Cterminal of apelin-13 : Influence on binding, biased signaling and receptor funcions. Neurosciences 2013 (43rd annual meeting of the Society for Neuroscience) November 9 -13 , 2013; San Diego, CA, USA th

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*Mylène Lafrance, Alexandre Murza, Élie Besserer-Offroy, Orlane Ballot, Jean-Michel Longpré, Richard Leduc, Thomas Stroh, Éric Marsault, Philippe Sarret: Impact of the incorporation of unnatural amino acids at the C-terminal end of the Apelin peptide on pain inhibition. 8 European Federation of IASP Chapters, October 9 -12 , 2013; Florence, Italy th

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*Alexandre Murza, Élie Besserer-Offroy, Mylène Lafrance, Alexandre Parent, Nicolas Beaudet, Richard Leduc, Philippe Sarret, Éric Marsault: Incorporation of unnatural amino acids in Apelin: influence on biased signaling and activity in animal models of pain. 3 Journée Scientifique du Réseau Québécois de Recherche sur le Médicament (RQRM); September 22 -23 , 2014; Montréal, Canada è

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*Andrea Brumwell, Élie Besserer-Offroy, Jean-Michel Longpré, Philippe Sarret, Richard Leduc: Molecular Signature of the Neurotensin Receptor 1. 9 Journée Scientifique de la FMSS (1 Cycle); September 13 , 2013; Sherbrooke, Canada è

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*Trang Dinh, Élie Besserer-Offroy, Alexandre Murza, Jean-Michel Longpré, Philippe Sarret, Richard Leduc, Éric Marsault: Élucidation de la relation structure-activité de l’Apéline : Influence d’acides aminés non naturels sur la signalisation du récepteur APJ. 9 Journée Scientifique de la FMSS (1 Cycle); September 13 , 2013; Sherbrooke, Canada è

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*Élie Besserer-Offroy, Michel Demeule, Nicolas Beaudet, Anthony Régina, Pascal Tétreault, Karine Belleville, Christian Ché, Alain Larocque, Jean E. Lachowicz, Jean-Paul Castaigne, Philippe Sarret: Use of peptide technology for analgesic brain delivery. 23rd American Peptide Symposium; June 22 -23 , 2013; Waikoloa, HI, USA – Published abstract nd

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*Élie Besserer-Offroy, Pascal Tétreault, Mylène Lafrance, Alexandre Murza, Adeline René, Jean-Michel Longpré, Florine Cavelier, Jean Martinez, Éric Marsault, Richard Leduc, Philippe Sarret: Deciphering the NTS1 receptor signalling pathways leading to analgesia and hypothermia. XXVII Symposium du GEPROM; June 12 -13 , 2013; Montréal, Canada e

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*Élie Besserer-Offroy, Pascal Tétreault, Mylène Lafrance, Alexandre Murza, Adeline René, Jean-Michel Longpré, Florine Cavelier, Jean Martinez, Éric Marsault, Richard Leduc, Philippe Sarret: Deciphering the NTS1 receptor signalling pathways leading to analgesia and hypothermia. 1 Colloque RQRMIndustrie; June 10 , 2013; Montréal, Canada er

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*Alexandre Murza, Élie Besserer-Offroy, Mylène Lafrance, Nicolas Beaudet, Richard Leduc, Philippe Sarret, Éric Marsault: Incorporation of unnatural amino acids in Apelin: influence on biased signaling and activity in animal models of pain. 96 Canadian Chemistry Conference and Exhibition; May 26 -30 , 2013; Québec, Canada th

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*Élie Besserer-Offroy, Jean-Michel Longpré, Dominic Devost, Billy Breton, Christian Le Gouil, Michel Bouvier, Éric Marsault, Philippe Sarret, Richard Leduc: BRET-Based Assay Development for the Discovery of Novel GPCR Ligands. Journée Phare 2012; November 16 , 2012; Orford, Canada th

*Alexandre Murza, Alexandre Parent, Élie Besserer-Offroy, Hugo Tremblay, Félix Karadereye, Nicolas Beaudet, Richard Leduc, Philippe Sarret, Éric Marsault: Structure/activity relationship and plasma stability studies of apelin’s peptide analogues. Journée Phare 2012; November 16 , 2012; Orford, Canada th

Philippe Sarret, *Pascal Tétreault, Alexandre Parent, Élie Besserer-Offroy, Alexandre Murza, Adeline René Isabelle Dubuc, Nicolas Beaudet, Richard Leduc, Éric Marsault, Jean Martinez, Florine Cavelier: Neurotensin receptor-based therapy: Achieving analgesia without opioid-related side effects. Neuroscience 2012 (42 Annual meeting of the Society for Neuroscience), October 13th-17th, 2012; New Orleans, LA, USA nd

*Alexandre Murza, Alexandre Parent, Élie Besserer-Offroy, Hugo Tremblay, Félix Karadereye, Nicolas Beaudet, Richard Leduc, Philippe Sarret, Éric Marsault: Structure/activity relationship and plasma stability studies of apelin’s peptide analogues. 32 European Peptide Symposium; September 2 -7 , 2012; Athens, Greece nd

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*Mylène Lafrance, Alexandre Murza, Élie Besserer-Offroy, Sabrina Bossé, Nicolas Beaudet, Richard Leduc, Thomas Stroh, Éric Marsault, Philippe Sarret: Analgesic effect of Apelin and structural analogs on pain modulation. 14 World Congress on Pain (IASP); August 27 -31 , 2012; Milan, Italy th

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*Pascal Tétreault, Alexandre Parent, Élie Besserer-Offroy, Alexandre Murza, Adeline René, Isabelle Dubuc, Nicolas Beaudet, Richard Leduc, Éric Marsault, Jean Martinez, Florine Cavelier, Philippe Sarret: Pain relief devoid of opioid side effects following central action of a new neurotensin analog. 14 World Congress on Pain (IASP); August 27 -31 , 2012; Milan, Italy th

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*Alexandre Murza, Alexandre Parent, Élie Besserer-Offroy, Hugo Tremblay, Félix Karadereye, Nicolas Beaudet, Philippe Sarret, Éric Marsault: Relation structure-activité et stabilité plasmatique de nouveaux analogues de l’Apéline. 41e Journée Scientifique de la FMSS; March 28 , 2012; Sherbrooke, Canada th

*Pascal Tétreault, Alexandre Parent, Élie Besserer-Offroy, Adeline René, Isabelle Dubuc, Nicolas Beaudet, Richard Leduc, Éric Marsault, Jean Martinez, Florine Cavelier, Philippe Sarret: Soulager la douleur sans effets secondaires : la promesse d’un nouvel analogue de la Neurotensine. 41e Journée Scientifique de la FMSS; March 28 , 2012; Sherbrooke, Canada th

*Gabriel Bouffard-Bonin, Pascal Tétreault, Alexandre Parent, Élie Besserer-Offroy, Philippe Sarret: Caractérisation des effets moléculaires et comportementaux du JMV2009, un agoniste neurotensinergique activant les récepteurs NTS1 et NTS2. 6e Journée Scientifique de la FMSS (1 Cycle); November 18 , 2011; Sherbrooke, Canada st

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*Mylène Lafrance, Alexandre Murza, Élie Besserer-Offroy, Sabrina Bossé, Nicolas Beaudet, Richard Leduc, Éric Marsault, Philippe Sarret: Involvement of Apelin in pain modulation. Neuroscience 2011 (41 Annual meeting of the Society for Neuroscience); November 12 -16 , 2011; Washington DC, USA st

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Élie Besserer-Offroy – Curriculum Vitae

2016-03-24

*Alexandre Murza, Alexandre Parent, Élie Besserer-Offroy, Hugo Tremblay, Félix Karadereye, Nicolas Beaudet, Richard Leduc, Philippe Sarret, Éric Marsault: Structure activity relationship and plasma stability studies of apelin’s peptide analogues. 94 Canadian Chemistry Conference and Exhibition; June 5 -9 , 2011; Montréal, Canada th

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*Alexandre Murza, Alexandre Parent, Élie Besserer-Offroy, Hugo Tremblay, Félix Karadereye, Nicolas Beaudet, Richard Leduc, Philippe Sarret, Éric Marsault: Relation structure/activité et etudes de stabilité plasmatique d’analogues peptidiques de l’Apéline. 79e Congrès de l’ACFAS; May 9 -13 , 2011; Sherbrooke, Canada th

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