UNIVERSITY OF PÉCS MEDICAL CHEMISTRY FINAL EXAM SAMPLE 1st year, 2nd semester ………………………………………… name ………….. group MRT:
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Exam:
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Practice:
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Total:
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Mark:
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SAMPLE MINIMUM REQUIREMENTS TEST 1/29. Characterisation of σ-bonds (what types of atomic orbitals may form σ-bonds?)
2/13. Freeze drying (lyophilization).
3/1. Ions responsible for the hardness of water (list).
4/19. Definition of catalysis.
5/29. Formula and usage of vinyl chloride.
6/22. Write equation for the addition of HCN to an oxo compound.
7/22. Structural formula of the peptide glycyl alanine.
SAMPLE 8/12. The role of glucuronic acid in detoxification.
9/20. List of differences in structures of DNA and RNA.
10/9. Isomers of the diamminedichloroplatinum(II) complex (figures).
11/3. Transportation ratio of Na+ and K+ ions through the plasma membrane (Na+-K+ pump).
12/7. Basic functions of ceruloplasmin (list).
13/2. Definition of silicosis.
14/2. Hydrolysis of sodium carbonate (equations).
Points:
/30p
Passed/Failed .………………….. signature
SAMPLE
TEST QUESTIONS 1. a. Why is the atom neutral?
1p
b. Give the definition of the atomic orbital.
2p
2. How does the size of the halogen atoms change in the 7th group of the periodic table from fluorine to iodine? State your reason.
2p
3. Compare the following three compounds.
6p
Molecule
HF
CH4
H2S
- shape: - polarity: The oxidation number of the central atom: The strongest interaction which holds the particles together in solid phase: 4. An ionic compound is dissolved in water. When is the dissolution exothermic, and when is it endothermic? (Compare the energies which has contributon to the heat of dissolution). 3p
SAMPLE 5. a. Give the definition for buffer solutions.
2p
b. Give the Henderson-Hasselbalch-equation suitable for the calculation of the pH value of a buffer solution.
2p
c. Define the term ’buffer capacity’.
2p
d. What is the biological importance of buffer solutions?
2p
e. How does the dilution change the pH and buffer capacity of a buffer solution? (e.g. a buffer solution is diluted to double volume).
2p
6. What can be concluded from the sign (+, -, 0) of the free enthalpy change of a chemical reaction?
2p
7. List the following solutions in increasing order on the base of their osmotic pressure. 2p 1M NaCl solution
1M glucose solution 1M Na3PO4 solution
1M K2SO4 solution
SAMPLE 8. Draw the resonance formulas of the sulphate ion and give their resonance hybride.
2p
9. How can the rate determining step be selected in consecutive reactions? How does the rate determining step influence the observed reaction rate?
2p
10. a. Depict a silver - silver chloride electrode.
2p
b. What kind of electrode is it?
1p
c. What is its practical use?
1p
d. Give the formula suitable for the calculation of the electrode potential of the above electrode. Explain the denotations.
3p
11. Give the formulas of the following compounds:
4p
a. pyridine b. tertiary-butyl-alcohol c. resorcine d. vinylchloride
SAMPLE 12. Give the formulas of fumaric acid and maleic acid. What is the relationship between them? State your reason.
4p
13. What does the order of alcohols mean? Give examples.
3p
14. What kind of mechanism is the halogenation of alkenes? Give the elementary steps (detailed mechanism) for the chlorination of methane.
4p
15. Classify the dienes on the base of the position of the double bonds.
3p
SAMPLE 16. Give reaction equations. a., bromination of benzaldehyde
b. formation of maleic acid anhydride
c. methylamine + iso-propyl-chloride
d. oxidation of isopropanol
8p
17. a. Give the formula of salicylic acid.
1p
b. Give the equation for the reaction of salicylic acid with acetic anhydride.
2p
c. What is the medical significance of the product of the above reaction?
1p
SAMPLE 18. a. Name the following compound.
1p CH3
CH3
H
OH
H H
O
b. Number the carbon atoms.
1p
c. Which family of steroids does the above compound belong to?
1p
d. Give the type, the order and the strecic orientation (α- or β) of the hydroxyl group on the D ring.
3p
e. Give the ring junctions of B – C and C – D rings.
2p
f. What happens if this molecule is mildly oxidized?
2p
g. What is the biological, medical importance of the above compound?
1p
19. Give the definition of waxes. What kind of compounds are they? What is their biological function?
2p
20. List three opium alkaloids.
3p
SAMPLE
21. a. Name the following compound.
1p
CH3
O
CH3
O
O
H3 C O
H3C
K
O
O
CH3
O CH3
O
O
CH3
O
O CH3
b. What is the coordination number of potassium in the above compound?
1p
c., What is the practical importance of this compound?
1p
d., List the types of ligands which form complexes with alkali metals.
3p
e., Give the definition of chelate complexes.
2p
21. Which heteroelement can be found in the glutathion peroxidase enzyme? What is the biological function of this enzyme?
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