UNIVERSITY OF PÉCS MEDICAL CHEMISTRY FINAL EXAM SAMPLE 1st year, 2nd semester ………………………………………… name ………….. group MRT:
……… points
Exam:
……… points
Practice:
………points
Total:
………points
Mark:
………. ……………………… signature
SAMPLE MINIMUM REQUIREMENTS TEST 1/29. Characterisation of σ-bonds (what types of atomic orbitals may form σ-bonds?)
2/13. Freeze drying (lyophilization).
3/1. Ions responsible for the hardness of water (list).
4/19. Definition of catalysis.
5/29. Formula and usage of vinyl chloride.
6/22. Write equation for the addition of HCN to an oxo compound.
7/22. Structural formula of the peptide glycyl alanine.
SAMPLE 8/12. The role of glucuronic acid in detoxification.
9/20. List of differences in structures of DNA and RNA.
10/9. Isomers of the diamminedichloroplatinum(II) complex (figures).
11/3. Transportation ratio of Na+ and K+ ions through the plasma membrane (Na+-K+ pump).
12/7. Basic functions of ceruloplasmin (list).
13/2. Definition of silicosis.
14/2. Hydrolysis of sodium carbonate (equations).
Points:
/30p
Passed/Failed .………………….. signature
SAMPLE
TEST QUESTIONS 1. a. Why is the atom neutral?
1p
b. Give the definition of the atomic orbital.
2p
2. How does the size of the halogen atoms change in the 7th group of the periodic table from fluorine to iodine? State your reason.
2p
3. Compare the following three compounds.
6p
Molecule
HF
CH4
H2S
- shape: - polarity: The oxidation number of the central atom: The strongest interaction which holds the particles together in solid phase: 4. An ionic compound is dissolved in water. When is the dissolution exothermic, and when is it endothermic? (Compare the energies which has contributon to the heat of dissolution). 3p
SAMPLE 5. a. Give the definition for buffer solutions.
2p
b. Give the Henderson-Hasselbalch-equation suitable for the calculation of the pH value of a buffer solution.
2p
c. Define the term ’buffer capacity’.
2p
d. What is the biological importance of buffer solutions?
2p
e. How does the dilution change the pH and buffer capacity of a buffer solution? (e.g. a buffer solution is diluted to double volume).
2p
6. What can be concluded from the sign (+, -, 0) of the free enthalpy change of a chemical reaction?
2p
7. List the following solutions in increasing order on the base of their osmotic pressure. 2p 1M NaCl solution
1M glucose solution 1M Na3PO4 solution
1M K2SO4 solution
SAMPLE 8. Draw the resonance formulas of the sulphate ion and give their resonance hybride.
2p
9. How can the rate determining step be selected in consecutive reactions? How does the rate determining step influence the observed reaction rate?
2p
10. a. Depict a silver - silver chloride electrode.
2p
b. What kind of electrode is it?
1p
c. What is its practical use?
1p
d. Give the formula suitable for the calculation of the electrode potential of the above electrode. Explain the denotations.
3p
11. Give the formulas of the following compounds:
4p
a. pyridine b. tertiary-butyl-alcohol c. resorcine d. vinylchloride
SAMPLE 12. Give the formulas of fumaric acid and maleic acid. What is the relationship between them? State your reason.
4p
13. What does the order of alcohols mean? Give examples.
3p
14. What kind of mechanism is the halogenation of alkenes? Give the elementary steps (detailed mechanism) for the chlorination of methane.
4p
15. Classify the dienes on the base of the position of the double bonds.
3p
SAMPLE 16. Give reaction equations. a., bromination of benzaldehyde
b. formation of maleic acid anhydride
c. methylamine + iso-propyl-chloride
d. oxidation of isopropanol
8p
17. a. Give the formula of salicylic acid.
1p
b. Give the equation for the reaction of salicylic acid with acetic anhydride.
2p
c. What is the medical significance of the product of the above reaction?
1p
SAMPLE 18. a. Name the following compound.
1p CH3
CH3
H
OH
H H
O
b. Number the carbon atoms.
1p
c. Which family of steroids does the above compound belong to?
1p
d. Give the type, the order and the strecic orientation (α- or β) of the hydroxyl group on the D ring.
3p
e. Give the ring junctions of B – C and C – D rings.
2p
f. What happens if this molecule is mildly oxidized?
2p
g. What is the biological, medical importance of the above compound?
1p
19. Give the definition of waxes. What kind of compounds are they? What is their biological function?
2p
20. List three opium alkaloids.
3p
SAMPLE
21. a. Name the following compound.
1p
CH3
O
CH3
O
O
H3 C O
H3C
K
O
O
CH3
O CH3
O
O
CH3
O
O CH3
b. What is the coordination number of potassium in the above compound?
1p
c., What is the practical importance of this compound?
1p
d., List the types of ligands which form complexes with alkali metals.
3p
e., Give the definition of chelate complexes.
2p
21. Which heteroelement can be found in the glutathion peroxidase enzyme? What is the biological function of this enzyme?
Give the formula of the mass-action law for the dissociation of propionic acid (equation; explanation of ... Is the aqueous solution of AlCl3 acidic or alkaline?
Please obtain the signature of the Intercollegiate Manager (or designate) confirming your expected absence. ... mentioned team, representing McGill University.
Answer to each of the following questions (10 points each). .... While studying finance as a MBA student, you are approached by your uncle who wants you.
December 12th. Documents authorized,. Please use separate pages between Ex. 1 and Exs. (2,3,4),. Answer questions in the same order as they are listed,.
13.5 Case Study: Catalytic Mechanism of Yeast Enolase .... experiment for a broad array of physical observables (the first chapter is devoted in part ..... space, activation free energy for β-lactam hydrolysis and β-lactam CâN bond length. .....
restricted to designs with less than a total of 400 sampled trees. Krishnamani ..... viewed the vector f as a zero-censored outcome of sampling from a mixture of k ...
1. 3to increase by one X â X + 1, decrease by one, or stay the same. When X = 0, the transition probabilities are 1. 2 to go to one Xt = 0 â Xt + 1 = 1 or stay the ...
Prensa Española, 1975. Spires, Robert C. Post-Totalitarian Spanish Fiction. ..... Jean-Paul Sartre, L'Existentialisme est un humanisme. Simone de Beauvoir, Le ...
z are i.i.d. with respective variance Ï2 ... 2 â Interpret equation (2) of Extract 2 in relation with the course on the construction .... traditional Phillips curve analysis.
Jan 18, 2012 - primary key (sipaddress, contactaddress). ); ... The res-jndi-name element must refer to a data source configured in rhino-config.xml .... Answer the call on user agent B. This sends a SIP 200 OK response back to the proxy. 7.
Apr 13, 2011 - mance in simulation-based training: adopting best practices for healthcare. ... generation of doctors is both capable and competent. Bradley ...
Word/POS .... Indeed, a certain amount of manual work is still necessary, such as preparing .... Future work includes improvement of the system as well as using ...
We consider here a model inspired from the works of. Stan Fisher (1977) and John Taylor (1978). Consider an economy with a continuum of individuals indexed ...
M12 mâle à 4 positions. • Longueur max. du câble. 300 m [984 pi]. Environnement. • Plage de température. Opération. 0 à 60°C [32 à 140°F]. Entreposage.