CV: Prof. Jacques Corbeil Ph.D. CURRENT POSITION TITLE: Professor, Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec City, Quebec, Canada, G1V 0A6 EDUCATION/TRAINING INSTITUTION AND LOCATION Université Laval (Québec, Canada) Université Laval (Québec, Canada) University of New South Wales (Sydney, Australia) Postdoctoral Fellowship in Infectious Diseases division with Prof. Douglas D. Richman, University of California, San Diego, 1992-1995.

DEGREE (if applicable) BSc MSc PhD

MM/YY

FIELD OF STUDY

1982 1985

Biochemistry Experimental Medicine

1992

Medicine

01/199206/1995

Infectious diseases

A. Personal Statement Dr. Jacques Corbeil focuses on using the latest techniques in bioinformatics and machine learning to assist diagnostic, prognostic and response to treatment. Modern genomic and metabolomic techniques generate a deluge of data that need to be interpreted using novel bioinformatics approaches. Dr. Corbeil is using stateof-the-art instrumentation and methodologies to facilitate the interpretation of complex data. Dr. Corbeil’s research includes investigating how infectious microorganisms interact with their host, the effects of antibiotics on our microbial flora, exploring how to design small molecules and drugs to interfere with specific microbial functions and integration of omics specifically in cancer research data. Dr. Corbeil has also numerous projects investigating environmental microbiomes and industrial processes. Dr. Corbeil operates at the interface of computer sciences and omic sciences. He recently created the Big Data Research Centre at Université Laval with colleague François Laviolette. Since 2004, Dr. Corbeil holds the Canada Research Chair in Medical Genomics (Tier 1) which was renewed until 2025. B. Work experience 2001 - 2006 1998 - 2006 1996 - 2006 1996 - 2000 1995 - 1996

Associate Professor, University of California, San Diego, School of Medicine, Infectious Diseases division and AIDS Research Institute. Director, UCSD Center for AIDS Research and Veterans Medical Research Foundation Genomics core laboratory. Research Scientist, Veterans Medical Research Foundation. Department of Medicine, University of California, San Diego Assistant Professor Department of Pathology, University of California, San Diego, Assistant Research Virologist level 2.

C. Corporate collaborations, accomplishment and honours Scientific Advisory Board member for Gelantis, San Diego, CA (Ongoing). Scientific Advisory Board member and consultant for Autogenomics, San Diego, CA (terminated in 2014). Consultant for Silicon Kinetics, San Diego, CA (Ongoing). Founder Génocéan, Québec, Canada (2005-). Consultant for Salmedix. San Diego,CA (Sold to Cephalon). Scientific evaluator for Fond de Solidarité du Québec F.T.Q., Investment company, Montréal, Canada, Scientific evaluator for Business Development Bank of Canada Scientific evaluator for BackBay Management, Angel funding, Boston USA. Collaboration with Waters inc. Milford, USA (Ongoing). Consultant for Peaxy inc, San José, California (Ongoing) IAB CIHR Cancer Research Institute (2005-2009)

2

Biographical Sketch of Prof. J. Corbeil

Gairdner Foundation Medical Review Panel (2005-2012) Canadian Institutes Health Research Advisory Board for the committee on Health Innovation (2016-2017) Canadian Space Agency Expert health committee for International Space Station and deep space missions (2017-present) Board member, Compute Canada (2017-present) IAB CIHR Cancer Research Institute (2017-present) Editorial Board Proteome Science journal Career numbers • Number of Publications: • Book Chapters: • Patents: • Funding since 2011: • H index (Google Scholar):

126 4 2 > 16 M $ CAN and >5M as Principal Investigator 48 (> 8100 citations)

D. GRADUATE STUDENTS AND PERSONNEL Graduate students Pier-Luc Plante, Ph. D. Student Molecular Medicine, FRQ-S fellowship Maxime Déraspe, Ph. D. Student Molecular Medicine, FRQ-S fellowship Prudencio Tossou, Ph. D. Student Informatics Francis Brochu, Ph. D. Student Informatics, FRQ-S fellowship Alexandre Drouin, Ph. D. Student Informatics, CRSNG fellowship Mazid Osseni, Ph. D. Student Informatics, MITACS-Converge fellowship Baptiste Bauvin Ph.D. Student Informatics Project manager Frédéric Raymond Ph.D. (starts as an assistant professor at U. Laval in 2/2018) Undergraduate students Élina Francovic-Fontaine (2017-) Christophe Duchesne-Ashworth (2017-) Francis Brière (2017-) Rogia Kpanou (2017-) Research Professionals Nancy Boucher M.Sc. Katy Cantin Ph.D. Emilie Pic Ph.D. Laboratory Manager Lynda Robitaille B.Sc. MBA Visiting Professor Omar Triana Chavez Ph.D. Professor Antioquia University, Colombia (2017-)

E. PEER-REVIEWED PAPERS Publications (2011-present) 77. Shah M, Marchand M, Corbeil J. Feature Selection with Conjunctions of Decision Stumps and Learning from Microarray Data. IEEE Trans Pattern Anal Mach Intell. 2011 Apr 27.

Biographical Sketch of Prof. J. Corbeil

78. Shah, M and Corbeil J. A General Framework for Analyzing Data from Two Short Time-Series Microarray Experiments. IEEE/ACM Transactions on Computational Biology and Bioinformatics, IEEE/ACM Trans Comput Biol Bioinform. 2011 Jan-Feb;8(1):14-26 79. Laforge, M., Campillo-Gimenez, L., Fay, M., Cumont, M-C., Hurtrel, B., Corbeil J., Zaunders, J., Elbim, C., and Estaquier J. HIV/SIV infection primes monocytes and dendritic cells for apoptosis. 2011 PLoS Pathog. Jun;7(6):e1002087. 80. Do Monte-Neto RL, Coelho AC, Raymond F, Légaré D, Corbeil J, Melo, M.N., Frézard, F., Ouellette, M. 2011 Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis. PLoS Negl Trop Dis 5(5): e1167. 81. Huot JL, Fischer F, Corbeil J, Madore E, Lorber B, Diss G, Hendrickson TL, Kern D, and Lapointe J. Gln-tRNAGln synthesis in a dynamic transamidosome from Helicobacter pylori, where GluRS2 hydrolyzes excess Glu-tRNAGln. Nucleic Acids Res. 2011 Nucleic Acids Res. Nov;39(21):9306-15. 82. Rousseau J, Chapdelaine P, Boivert S, Almeida LP, Corbeil J, Montpetit A, Tremblay JP. Endonucleases: tools to correct the dystrophin gene. J. Gene. Med 2011 Oct;13(10):522-37. 83. Raymond, F., Boisvert, S., Roy, G., Ritt, J-F., Légaré, D., Isnard, A., Stanke, M., Olivier, M., Tremblay, MJ., Papadopoulou, B., Ouellette, M. and Corbeil, J. Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species. Nucleic acids research. 2012 Feb 1;40(3):1131-47. 84. Sirois, M., Robitaille, L., Allary, R. Shah, M., Woelk, CH., Estaquier, J., and Corbeil, J. TRAF6 and IRF7 control HIV replication in macrophages. PLOS ONE 2011;6(11):e28125. Nov 28. 85. Varin, T., Lovejoy, C., Jungblut, A., Vincent, W., Corbeil, J. Metagenomic analysis of stress genes in microbial mat communities from Antarctica and the extreme High Arctic. Applied and environmental microbiology 2012 Jan;78(2):549-59. Epub 2011 Nov 11. 86. Nolin, M.A., Dumontier, M., Belleau, F., Corbeil, J. Building an HIV data mashup using Bio2RDF. Briefing in Bioinformatics. 2012 Jan;13(1):98-106. Epub 2011 Mar 24. 87. Papenburg, J., Carbonneau, J., Hamelin, M-E., Isabel, S., Bouhy, X., Ohoumanne, N., Déry, P., Paes, B.A., Corbeil, J., Bergeron, M.G., De Serres, G., and Boivin, G. Molecular Evolution of Respiratory Syncytial Virus Fusion Gene and Surveillance for Mutations in the Palivizumab Binding Site, Canada, 2006-2010. Emerging Infectious Diseases. Emerg Infect Dis. 2012 Jan;18(1):120-4. 88. Coelho AC, Boisvert S, Mukherjee A, Leprohon P, Corbeil J, Ouellette M. Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing. PLoS Neglected Tropical Diseases. 2012 Feb;6(2):e1512. 89. Papenburg, J., Hamelin, M-E., Ouhoummane, N., Carbonneau, J., Ouakki, M., Raymond, F., Robitaille, L., Corbeil, J., Caouette, G., Frenette, L., De Serres, G., Boivin G. Comparison of Risk Factors for Human Metapneumovirus and Respiratory Syncytial Virus Disease Severity in Young Children. J Infect Dis. 2012 May 2. 90. Gervaix A, Taguebue J, Bescher BN, Corbeil J, Raymond F, Alcoba G, Kobela M, Tetanye E. Bacterial Meningitis and Pneumococcal Serotype Distribution in Children in Cameroon. Pediatr. Infect Dis J. 31, 1084 (2012). 91. Wie, S-H., Luong, T., Rought, S.E., Du, P., Beliakova-Bethell, N., Lozach, J., Corbeil, J., Kornbluth, R.S., Richman, D.D., Woelk, C.H. HIV Downregulates Interferon Stimulated Genes in Primary Macrophages. Journal of Interferon & Cytokine Research, 2012 Dec 31. PMID: 23276142. 92. Chappuy, H., Keitel, K., Gehri, M., Tabin, R., Robitaille, L., Raymond, R., Corbeil, J., Maspoli, V., Alcoba, G., Lacroix, L., Manzano, S., Galetto-Lacour, A., Gervaix A.. Nasopharyngeal carriage of individual Streptococcus pneumoniae serotypes during pediatric radiologically confirmed community acquired pneumonia following PCV7 introduction in Switzerland. BMC Infect Dis. 2013 Jul 31;13:357. doi: 10.1186/1471-2334-13-357. 93. Boisvert, S., Raymond, F., Godzaridis, É., Laviolette, F., Corbeil, J. Ray Meta: Massively distributed de novo metagenome assembly with coupled profiling. Genome Biology. 2012 Dec 22;13(12):R122. PMID: 23259615 94. Giguère, S., Marchand, M., Laviolette, F., Drouin, A. Corbeil, J. Learning a peptide protein binding affinity predictor using kernel ridge regression. BMC Bioinformatics. 2013 Mar

3

Biographical Sketch of Prof. J. Corbeil

5;14(1):82. PMID: 23497081. 95. Xu, Y., Weatherall, C., Bailey, M., Alcantara, S., De Rose, R., Estaquier, J., Wilson, K., Suzuki, K., Corbeil, J., Cooper, D., Kent, S., Kelleher, A., Zaunders, J. SIV Infects Follicular Helper CD4 T cells in Lymphoid Tissues During Pathogenic Infection of Pigtail Macaques. J. Virol. 2013 Jan 16. PMID: 23325697 96. Mukherjee, A, Boisvert, S, Lima do Monte-Neto, R., Coelho, A. Raymond, F. Mukhopadhyay, R., Corbeil, J., Ouellette, M. Telomeric gene deletion and intrachromosomal amplification in antimony resistant Leishmania. Molecular Microbiology. 2013,88 189-202. DOI: 10.1111/mmi.12178. 97. Kumar, P., Lodge, R., Raymond, F., Ritt, JF., Jalaguier, P., Corbeil, J., Ouellette, M., Tremblay, M.J. Gene expression modulation and the molecular mechanisms involved in Nelfinavir resistance in Leishmania donovani axenic amastigotes. Molecular Microbiology. 2013, 89:565-582 doi: 10.1111/mmi.12298. 98. Bradnam, KR., Fass, J.N., Alexandrov, A., Baranay, P., Bechner, M., Birol, I., Boisvert, S., Chapman, J.A., Chapuis, G., Chikhi, R., Chitsaz, H., Chou, W-C., Corbeil, J., et.al. Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species. 2013. Gigascience. 2(1):10. DOI:10.1186 99. Dionne, L-L., Raymond, F., Corbeil, J., Longtin, J., Gervais, P., Longtin, Y. Correlation between Clostridium difficile bacterial load, commercial real-time PCR cycle thresholds, and results of diagnostic tests based on enzyme immunoassay and cell-culture cytotoxicity assay. J. Clin. Micro. 2013 Nov;51(11):3624-30. doi: 10.1128/JCM.01444-13 PMID:23966497 100. Raymond, F., Boucher, N., Allary, R., Robitaille, L., Lefebvre, B., Tremblay V., Corbeil., J.* Gervaix, A. * Serotyping of Streptococcus pneumoniae based on capsular genes polymorphisms. PLOS one 2013. 24;8(9):e76197. PMID: 24086706* shared senior authorship. 101. Giguère, S., Drouin, A., Lacoste, A., Marchand, M., Corbeil, J., Laviolette, F. MHC-NP: A tool for the prediction of peptides naturally processed by the MHC. J. Immunol. Methods. 2013; 400401:30-6. 102. Ritt JF, Raymond F, Leprohon P, Légaré D, Corbeil J, Ouellette M. Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum. PLoS Negl Trop Dis. 2013, 7(11):e2564. 103. Godzaridis, É, Boisvert, S., Xia, F., Kandel, M., Behling, S., Long, B., Sosa, C. P., Laviolette, F., Corbeil, J. Human Analysts at Superhuman Scales: What Has Friendly Software To Do? Big Data. 2013, 1(4): 227-236. doi:10.1089. 104. Lévesque*, S., Plante*, P.L., Mendis, N., Cantin, P., Marchand, G., Charest, H., Raymond, F. Huot, C., Goupil-Sormany, I., Desbiens, F., Faucher, S. P., Corbeil, J., Tremblay, C. Genomic characterization of a large outbreak of Legionella pneumophila serogroup 1 strains in Québec City, 2012. *Contributed equally. PLOS One. 2014. Aug 8;9(8):e103852. doi: 10.1371 105. Ubeda, J-F*., Raymond, F.,* Mukherjee, A., * Plourde, M., Gingras, H., Roy, G. Lapointe, A. Leprohon, P., Papadopoulou, B., Corbeil, J., Ouellette, M. *Contributed equally. Genome wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania. PLOS biology. 2014. May 20;12(5):e1001868. doi: 10.1371/journal.pbio.1001868 106. Pizzorno, A., Abed, Y., Plante, P-L., Carbonneau, J., Baz, M., Hamelin, M-E., Corbeil, J., Boivin, G. Evolution of oseltamivir resistance mutations in influenza A (H1N1) and A(H3N2) viruses during selection in experimentally-infected mice. Antimicrobial Agent Chemotherapy. 2014. Aug 11. pii: AAC.02956-14. 107. El Haddad, L, Ben Abdallah, N., Plante, P-L., Dumaresq, J., Labrie, S., Corbeil, J., St-Gelais, D., Moineau, S. Improving the safety of Staphylococcus aureus polyvalent phages by its production on a Staphylococcus xylosus strain. PLOS One 2014. Jul 25;9(7):e102600. doi: 10.1371/journal.pone.0102600. 108. Labrie, S., Dupuis, M-E., Tremblay, D., Plante, P.L., Corbeil, J., Moineau, S. A new Microviridae phage isolated from a failed biotechnological process driven by Escherichia coli. Applied and Environmental Microbiology 2014 Nov;80(22):6992-7000. doi10.1128/ AEM. 109. Retamal, M. Abed, Y., Corbeil, J., Boivin, G. Epitope mapping of the 2009 pandemic and the A/Brisbane/59/2007 seasonal (H1N1) hemagglutinins using monoclonal antibodies and escape mutants. J. Gen.Virol. 2014. Jul 30. pii: vir.0.067819-0. doi: 10.1099/vir.0.067819-0.

4

Biographical Sketch of Prof. J. Corbeil

5

110. Labrie, S.J., El Haddad, L., Tremblay, D.M., Plante, P-L., Wasserscheid, J., Dumaresq, J., Dewar, K., Corbeil, J., Moineau, S. First Complete Genome Sequence of Staphylococcus xylosus, a Meat Starter Culture and a Host to Propagate Staphylococcus aureus Phages. Genome announcements 01/2014; 2(4). DOI: 10.1128/genomeA.00671-14. 111. Giguère, S., Laviolette, F., Marchand, M., Tremblay, D., Moineau, S., Biron, É., Liang, X., Corbeil, J. Machine Learning Assisted Design of Highly Active Peptides for Drug Discovery. PLOS Computational Biology 2015. 10.1371/journal.pcbi.1004074. 112. Kos, V., Déraspe, M., McLaughlin, R., Whiteaker, J., Roy, P.H., Alm, R., Corbeil, J., Gardner, H. The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility. Antimicrobial Agent Chemotherapy. 2015 Jan;59(1):427-36. doi: 10.1128/AAC.03954-14. 113. Foster, M.W., Gerhardt, G., Robitaille, L., Plante, P-L., Boivin, G., Corbeil, J. Moseley, A.M. Targeted proteomics of human metapneumovirus in clinical samples and viral cultures. 2015, Analytical Chemistry, 87 (20), 10247-10254. 114. Sanchez N, Chapdelaine P, Rousseau J, Raymond F, Corbeil J, Tremblay JP. Characterization of frataxin gene network in Friedreich's ataxia fibroblasts using the RNA-Seq technique. Mitochondrion. 2016 Jun 25;30:59-66. doi:10.1016/j.mito.2016.06.003. [Epub ahead of print] PubMed PMID: 27350085. 115. Raymond F, Ouameur AA, Déraspe M, Iqbal N, Gingras H, Dridi B, Leprohon P, Plante PL, Giroux R, Bérubé È, Frenette J, Boudreau DK, Simard JL, Chabot I, Domingo MC, Trottier S, Boissinot M, Huletsky A, Roy PH, Ouellette M, Bergeron MG, Corbeil J. The initial state of the human gut microbiome determines its reshaping by antibiotics. ISME J. 2016 Mar;10(3):707-20. doi: 10.1038/ismej.2015.148. 116. Drouin, A., Giguère, S., Déraspe, M., Marchand, M., Tyers, M., Loo, V.G., Bourgault, A-M., Laviolette, F. Corbeil, J. Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons. BMC genomics 2016, 17 :754 117. Chaillot J, Cook MA, Corbeil J, Sellam A. Genome-Wide Screen for Haploinsufficient Cell Size Genes in the Opportunistic Yeast Candida albicans. G3: Genes, Genomes, Genetics (Bethesda). 2016 Dec 30. pii: g3.116.037986. doi: 10.1534/g3.116.037986. [Epub ahead of print] PubMed PMID: 28040776. 118. Pavey SA, Laporte M, Normandeau E, Gaudin J, Letourneau L, Boisvert S, Corbeil J, Audet C, Bernatchez L. Draft genome of the American Eel (Anguilla rostrata). Mol Ecol Resour. 2016 Oct 18. doi: 10.1111/1755-0998.12608. [Epub ahead of print] PubMed PMID: 27754597. 119. Maheux, A. Berube, E., Boudreau, D.K., Raymond, F., Corbeil, J., Roy, P.H., Boissinot, M., Omar R.F. Draft genome sequence of Criibacterium bergeronii gen.nov.s.nov.strain CCRI-22567T isolated from a vaginal sample of a woman with bacterial vaginosis. Genome announcements. 2016. 4 e00959-16. 120. Raymond, F., Déraspe, M., Boissinot, M., Bergeron, MG, Corbeil, J. Partial recovery of microbiomes after antibiotic treatment. Gut Microbes 2016. 7 (5), 428-434. 121. Déraspe M., Raymond, F., Culley, A., Laviolette, F., Corbeil, J. Ray Surveyor: a new phenetic tool for genomics. Molecular Biology and Evolution, in press. 122. Deshiere, A., Joly-Beauparlant, C., Breton, Y., Martinez-Ferrando, I, Hany, L., Ouellet, M., Raymond, F., Lodge, R., Barat, C., Roy, M-A., Lyashkov A., Colquhoun, D.R., Graham, D.R., Corbeil, J., Tremblay, M.J. Global Mapping of the Macrophage-HIV-1 Transcriptome Reveals that Productive Infection Induces Remodeling of Host Cell DNA and Chromatin. Scientific Reports. 2017 DOI:10.1038/s41598-017-05566-9 123. Brisebois, E., Veillette, M., Culley, A., Dion Dupont, V., Corbeil, J., Lavoie, J., Duchaine, C. Human viral pathogens are pervasive in wastewater treatment center aerosols. J. Environmental Sciences 2017 In press 124. Maheux AF, Boudreau DK, Bérubé È, Boissinot M, Raymond F, Brodeur S, Corbeil J, Isabel S, Omar RF, Bergeron MG. Draft Genome Sequence of a Sporulating and Motile Strain of Lachnotalea Glycerine Isolated from Water in Québec City, Canada. Genome Announc. 2017 Oct 19;5(42). pii: e01059-17. doi:10.1128/genomeA.01059-17. PubMed PMID: 29051240; PubMed Central PMCID: PMC5646393. 125. Maheux AF, Boudreau DK, Bérubé È, Boissinot M, Raymond F, Brodeur S, Corbeil J, Brightwell G,

Biographical Sketch of Prof. J. Corbeil

6

Broda D, Omar RF, Bergeron MG. Draft Genome Sequence of Romboutsia maritimum sp. nov. Strain CCRI-22766(T), Isolated from Coastal Estuarine Mud. Genome Announc. 2017 Oct 12;5(41). pii: e01044-17. doi: 10.1128/genomeA.01044-17. PubMed PMID: 29025937; PubMed Central PMCID: PMC5637497. 126. Maheux AF, Boudreau DK, Bérubé È, Boissinot M, Cantin P, Raymond F, Corbeil J, Omar RF, Bergeron MG. Draft Genome Sequence of Romboutsia weinsteinii sp. nov. Strain CCRI-19649(T) Isolated from Surface Water. Genome Announc. 2017 Oct 5;5(40). pii: e00901-17. doi: 10.1128/genomeA.00901-17. PubMed PMID: 28982987; PubMed Central PMCID: PMC5629044. 127. Brochu, F., Plante, P.L., Drouin, A., Laviolette, F., Marchand, M., Corbeil, J. Virtual Lock Masses: an algorithmic method to enable mass spectra comparison in untargeted studies. In preparation.

F. GRANT SUPPORT RECEIVED IN THE PAST 5 YEARS •

• • •

Canada Research Chair in Medical Genomics, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, du 2018-01-01 au 2025-12-31 (1,4M$/7 years) Acquisition of High content analyser and nextgen sequencing for monitoring genomic health and disease states. Canadian Foundation for Innovation. Leaders funds. (520,000$) 2018 Acquisition of mass spectrometry instrumentation. Canadian Foundation for Innovation. Leaders funds. (225,000$) 2018. Evaluation of blood products in health and disease using machine learning and high throughput mass spectrometry, Subvention, MITACS Inc., Converge Project Proposal, du 2016-03-01 au 201902-28 ($414,000/3 years)

•

Comprehensive environmental monitoring and valorisation: From molecules to microorganisms, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Fonds d'excellence en recherche Apogée Canada, du 2016-04-01 au 2018-03-31

•

Advanced study of unconventional oil behaviour, innovative emergency measures to surface water oil spills: protection of water sources, Partenariat, Conseil de recherches en sciences naturelles et génie Canada, Subventions de projets stratégiques (SPS), du 2016-09-30 au 2019-09-29

•

Croissance de Legionella pneumophila dans les systèmes hydriques: comprendre la relation entre son génome et le microbiome., Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, du 2015-04-01 au 2018-03-31

•

Deciphering breast cancer HER2-negativity with regard to HER2-targeted therapy, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, du 2016-07-01 au 202006-30

•

Technologies for microbiome science and engineering. CREATE/NSERC. 2017-2023. (1,650,000$/6 years) Chaire de recherche du Canada en génomique médicale, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, du 2011-01-01 au 201712-31 (1,4M$/7 years) Merck-FMED-Université Laval. Role of extracellular mitochondria in adverse transfusion reactionsA prospective study. 2015-2017 (81,600$/2 years) Merck-FMED-Université Laval. Characterization of cellular signatures of viral infections to identify compounds with new antiviral indications against paramixoviruses. 2015-2017 (74,698$/2 years) FQRNT- Projet de recherche en équipe Croissance de Legionella pneumophila dans les systèmes hydriques : comprendre la relation entre son génome et le microbiome. 2015-2018 (48,000$/year for 3 years)

•

• • •

Biographical Sketch of Prof. J. Corbeil 7 • Computational and machine learning approaches to improve design and screening of high

• •

• • • •

•

• • • • •

bioactivity peptides for drug discovery, Subvention, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Concours CQDM-FOCUS, du 2014-12-01 au 2018-11-30 (1,5M$/4 years) Compute / Calcul Canada, Partenariat, Fondation Canadienne pour l'innovation (La), Programme des initiatives scientifiques majeures (ISM), du 2012-04-01 au 2017-03-31 System Biology of Cheddar, Subvention, Fonds de recherche du Québec - Nature et technologies, Programme de recherche en partenariat pour l'innovation en production et en transformation laitières - VI, du 2014-04-01 au 2017-03-31 (189,000$/3 ans) Large scale Machine Learning for AI. CREATE/NSERC. 2014-2018. (1,350,000$/5 years) Human and Microbial Integrative Genomics, Canadian Foundation for Innovation. Large scale infrastructure. 2013 (7,2M$) Human and Microbial Integrative Genomics, Canadian Foundation for Innovation, Large scale infrastructure operating funds. 2013 (876,000$) Improved quality control of blood products using high throughput mass spectrometry, Partenariat, Mathematics of Information Technology and Complex Systems (MITACS), Accélération Québec (MITACS/FQRNT), du 2014-05-26 au 2015-10-31 (80,000$) Improved quality control of blood products using high throughput mass spectrometry coupled to machine learning approaches, Partenariat, Fonds de recherche du Québec - Nature et technologies, du 2012-04-01 au 2015-03-31 (180,000$/3 years) Selectomics to monitor and predict the emergence of resistance to new therapeutic approaches. CQDM-Focus. (1,999,773$/3 years) Centre de recherche en infectiologie (CRI), Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, du 1996-06-01 au 2016-04-30 Acquisition of nextgen sequencing for monitoring genomic health and disease states. Canadian Foundation for Innovation. Leaders funds. (950,000$) 2011 Acquisition of nextgen sequencing for monitoring genomic health and disease states. Canadian Foundation for Innovation. Operating funds (114,000$) 2011 Machine learning integration of animicrobial resistance information to assist the medical decision, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement: La Résistance aux antimicrobiens, du 2016-06-01 au 2017-01-31