Intravenous Lidocaine Versus Intravenous Amiodarone (in a New
cedure was in accordance to Food and Drug Admin- istration regulations, plus the laws and regulations of each country where the study was performed. In-.
Intravenous Lidocaine Versus Intravenous Amiodarone (in a New Aqueous Formulation) for Incessant Ventricular Tachycardia John C. Somberg, MD, Steven J. Bailin, MD, Charles I. Haffajee, MD, Walter P. Paladino, MD, Nicholas Z. Kerin, MD, Duane Bridges, MD, Sandor Timar, MD, Janos Molnar, MD, and the Amio-Aqueous Investigators* The effectiveness of intravenous amiodarone for the treatment of incessant (shock resistant) ventricular tachycardia (VT) has not been established. This study evaluated the efficacy of a water-soluble amiodarone preparation or lidocaine for the treatment of shock-resistant VT. The trial was a double-blinded parallel design. Patients were randomized to receive up to 2 boluses of either 150 mg intravenous amiodarone or 2 boluses of 100 mg lidocaine followed by a 24-hour infusion. If the first assigned medication failed to terminate VT, the patient was crossed over to the alternative therapy. Twenty-nine patients were randomized to the study (18 received amiodarone and 11 received lidocaine). There were no significant differences between groups with
regard to baseline characteristics. Immediate VT termination was achieved in 14 patients (78%) with amiodarone versus 3 patients (27%) on lidocaine (p
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amiodarone versus placebo or versus a class Ic drug admin- istered for cardioversion of recent-onset (1 week) AF. Both blinded and open-label trials were ...
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