Short CV GUILLAUME WALTHER, PhD ASSOCIATE PROFESSOR Laboratory of Cardiovascular Pharm-Ecology, University of Avignon, France [email protected]

EDUCATION 2007: PhD in Human Movement Sciences. Speciality: Cardiovascular Physiology Title: « Vascular function and structure and muscle blood flow during exercise in elite athletes ». 2002: Master of Sciences. Speciality: Physiology and Physiopathology, dependence and performance regulation. 2004: Master in Biostatistics.

EMPLOYMENT HISTORY 2009-2010: Post-doctoral Research Fellow. Physiology & Physiopathology of Cardiovascular Adaptations to Exercise Lab, Avignon, France. 2007-2009: Post-doctoral Research Fellow. Heart and Lung Research Center, Québec, Canada. 2003-2007: Casual and Assistant Lecturer, University of Avignon, France.

RESEARCH ACTIVITY Research interests: • Cardiometabolic risks : effects on endothelial and myocardial function. • Amniotic stem cells therapy in cellular cardiomyoplasty. Technical skills: • Cardiac and vascular morphology and function investigation (ultrasound Doppler). • Experimental and clinical microcirculation (Laser Doppler and iontophoresis). • Heart rate variability (Holter), electrocardiography. • Cell culture, Flow cytometry, Immunofluorescence techniques. Most significant publications: D. Montero, G. Walther, A. Perez-Martin, E. Roche, A. Vinet. Endothelial dysfunction related to inflammation and oxidative stress, in obese children and adolescents: signs and lifestyle intervention. Obes Rev. 2011 Dec 1. doi: 10.1111/j.1467-789X.2011.00956.x. [Epub ahead of print] G. Walther, S. Nottin, A. Perez-Martin, M. Dauzat, P. Obert Flow-mediated dilation and exercise-induced hyperemia in highly-trained athletes: comparison of the upper and lower limb vasculature. Acta Physiologica. 2008 Jun;193(2):139-50. G. Walther, S. Nottin, M. Dauzat, P. Obert Femoral and axillary ultrasound blood flow measurement during exercise: a methodological study. Med Sci Sports Exerc. 2006 Jul;38(7):1353-61. G. Walther, J. Gekas, O. Bertrand Amniotic Stem Cells for Cellular Cardiomyoplasty: Potentials and Pitfalls. Catheter Cardiovasc Interv. 2009 Jun 1;73(7):917-24.

COMPETITIVE GRANTS HISTORY • • • • • • •

Arterial stiffness and vasomotion relates to mediacalcification in highly-trained athletes, 2012, French Society of Cardiology, France. PI : G. Walther. 15 000€. End : 2013. Macro and microcirculation in obese children : implication of inflammation and oxidative stress, 2010-2011, French Society of Vascular Medecine, France. PI : A. Vinet, Co-I: G. Walther. 22500€. End : 2012. RESOLVE Study : Effects of exercise and nutritional program on bone, heart and muscle in metabolic syndrome, 2009-2010, Heart and Artery Foundation, France, PI: Lesourd B, Co-I: G. Walther. 235000€. Amniotic stem cells: bridge to heart transplantation, 2007-2008, Quebec Foundation for Health Research, Canada. PI: G. Walther. 90000$. Cardiovascular function and structure in highly-trained athletes, 2004-2007, University Hospital of Nimes, France, PI: G. Walther. 3000€. Effect of chronic exercise on cardiovascular function and structure in young and adult obese and diabetic subjects, 2004-2007, French Health Ministery, PI: Perez-Martin A, Co-I: G. Walther. 25000€. Functional adaptation in cardiac and skeletal muscle in HIV-infected patients receiving highly active antiretroviral therapy, 2004-2006, ANRS, PI: Thöni G, Technical expertise: G. Walther. 58000€.

Detailed document Research activity…………………………………………………………………………………. 3 Teaching…………………………………………………………………………………………... 8 Referees……………………………………………………………………………………………9

WALTHER Guillaume, PhD Date of birth: March 8, 1979 Nationality: French Marital status: Single Home address: 11 Rue de l’Oriflamme 84000 AVIGNON Phone number:+33(0)622371510

Professional address: Laboratory of Cardiovascular Pharm-Ecology EA4278 Faculty of Sciences, University of Avignon 33 Rue Louis Pasteur Avignon, France Phone number:+33(0)490162931 [email protected]

EMPLOYMENT HISTORY 2010-present 2009-2010

Associate Professor. Laboratory of Cardiovascular Pharm-Ecology, Avignon, France. Post-doctoral Research Fellow. Physiology & Physiopathology of Cardiovascular Adaptations to Exercise Lab, Avignon, France. RESOLVE Project : Effects of a lifestyle modification intervention on the cardiometabolic risk factors and health related qualities of life in patients with metabolic syndrome. Casual Lecturer at School of Sport Sciences, University of Avignon, France. Casual Lecturer at School of Nursing, Avignon, France.

2007-2009

Post-doctoral Research Fellow. Heart and Lung Research Center, Québec, Canada.

2003-2007

Casual and Assistant Lecturer at School of Sport Sciences, University of Avignon, France

EDUCATION 2003-2007

Ph.D. Human Movement Sciences Speciality: Cardiovascular and Exercise Physiology « Vascular function and structure and muscle blood flow during exercise in elite athletes ». Supervisor: Prof. Philippe OBERT Physiology & Physiopathology of Cardiovascular Adaptations to Exercise Lab, Avignon, France.

2002-2004

University Diploma in Biostatistics (Master) Faculty of Sciences, University of Strasbourg, France.

2000-2002

Master of Sciences Speciality: Physiology and Physiopathology. Supervisors: Prof. Jean LONSDORFER and Dr. Laurence RASSENEUR Laboratory of Respiratory and Functional Investigations Hospital of Strasbourg, France.

1997-2000

B.Sc in Sport and Exercise Sciences Speciality: Exercise Performance and Ergonomy UFR STAPS, Faculty of Strasbourg, France.

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I. RESEARCH ACTIVITY KEY WORDS Endothelial function, blood flow, myocardial function, exercise, athletes, metabolic disorders, cellular therapy. I have conducted and collaborated to several research projects since I have started my research experience. I have been mainly interested in the physiological alterations of the cardiovascular function in healthy subjects as well as in diseased patients in response to acute or chronic exercise. More recently, to develop new experimental skills in the cardiovascular field, I have been investigating cellular therapy in cardiomyoplasty during a postdoctoral experience in Quebec, Canada. More specifically, I have explored: 1. The effect of metabolic disorders on endothelial and myocardial function at rest and during exercise and the effect of lifestyle modification intervention on the cardiometabolic risk factors. 2. The vascular structure and function and muscle perfusion during isolated dynamic exercises and the vascular adaptive changes obtained by intensive exercise training in highly-trained athletes. 3. The ability of human amniotic stem cells to be used in cellular cardiomyoplasty.

PUBLICATIONS Article submitted Original peer reviewed publications 1 - D. Montero, G. Walther, A. Perez-Martin, E. Roche, A. Vinet. Endothelial dysfunction related to inflammation and oxidative stress, in obese children and adolescents: signs and lifestyle intervention. Obes Rev. 2011 Dec 1. doi: 10.1111/j.1467-789X.2011.00956.x. [Epub ahead of print] 2 - A. Vinet, L. Karpoff, G. Walther, L. Goret, M. Dauzat, A. Perez-Martin. Short-term exercise training normalizes vascular dysfunction at rest but does not improve mucle perfusion during exercise in obese men. Int J Obesity. 2011 Jun;35(6):820-8. 3 - G. Walther, J. Gekas, D. Skuk, E. Larose, O. Costerousse, E. Bujold, O. Bertrand. Ability of human amniotic fluid derived stem cells to differentiate into myogenic lineage. Clin Exp Med. 2010 Mar;10(1):1-6. 4 - G. Walther, J. Gekas, O. Bertrand Amniotic Stem Cells for Cellular Cardiomyoplasty: Potentials and Pitfalls. Catheter Cardiovasc Interv. 2009 Jun 1;73(7):917-24. Review. 5 - G. Thöni, I. Schuster, G. Walther, S. Nottin, A.Vinet, F. Boccara, JM. Mauboussin, I. Rouanet, S. Edérhy, M. Dauzat, P. Messner-Pellenc, P. Obert Silent cardiac dysfunction and exercise intolerance in HIV+ men receiving combined antiretroviral therapies. AIDS. 2008 Nov 30;22(18):2537-40. 6 - G. Walther, S. Nottin, A. Perez-Martin, M. Dauzat, P. Obert Flow-mediated dilation and exercise-induced hyperemia in highly-trained athletes: comparison of the upper and lower limb vasculature. Acta Physiologica. 2008 Jun;193(2):139-50. 7 - I. Schuster, G. Thöni, S. Edérhy, G. Walther, S. Nottin, A.Vinet, F. Boccara, M. Khireddine, JM Mauboussin, I. Rouanet, A. Cohen, P. Obert, P. Messner-Pellenc and the Heart and Muscle Study Group / GECEM 3

Subclinical cardiac abnormalities in HIV-infected men under antiretroviral therapy. Am J Cardiol. 2008 Apr 15;101(8):1213-7. 8 - T. Rowland, V. Bougault, G. Walther, S. Nottin, A.Vinet, P. Obert Cardiac responses to swim bench Exercise in age-group swimmers. J Sci Med Sport. 2009 Mar;12(2):266-72. 9 - J. Barbier, N. Ville, G. Kervio, G. Walther, F. Carré Sport-specific features of athlete’s heart and their relation to echocardiographic parameters. Herz. 2006 Sep;31(6):531-543. 10 - G. Walther, S. Nottin, M. Dauzat, P. Obert Femoral and axillary ultrasound blood flow measurement during exercise: a methodological study. Med Sci Sports Exerc. 2006 Jul; 38(7):1353-61. 11 - S. Nottin, G. Walther, A. Vinet, L. Beck, P. Messner-Pellenc, M. Dauzat, P. Obert Reproducibility of automated pulse wave velocity measurement during exercise. Arch Mal Coeur Vaiss. 2006 Jun; 99(6):564-8. PUBLISHED COMMUNICATIONS Abstract published in peer reviewed journals 1 - G. Walther, P. Obert, F. Dutheil, R. Chapier, A. Camus, D. Courteix, G. Lac, B. Lesourd, A. Vinet. Metabolic Syndrome alters Skin Microcirculatory Vasoreactivity in Human – Preliminary Results. Archives of Cardiovascular Diseases ; 3, S1, 2011. IF : 0.305 2 - G. Walther, J. Gekas, D. Skuk, E. Larose, O. Costerousse, E. Bujold, J. Tremblay, O. Bertrand. Human c/kit+ amniotic fluid derived stem cells: first step in vitro and in vivo before cardiomyoplasty. European Heart Journal (2009) 30 (Abstract Supplement), 503. IF : 8.917 3 - G. Walther, J. Gekas, D. Skuk, E. Larose, O. Costerousse, E. Bujold, J. Tremblay, O. Bertrand. Human c/kit+ amniotic fluid derived stem cells: ready to be used in cellular cardiomyoplasty ? Archives of Cardiovascular Diseases ; 102 (1), S127, 2009. IF : 0.305 4 - J. Martin, G. Walther, C. Julien, S. Biron, S. Marceau, S. Lebel, F. Hould, L. Biertho, P. Poirier. Dichotomic Effect of Weight Loss Following Bariatric Surgery on QTc interval. Circulation; 119:e289, 2009. IF : 14.595 5 - J. Martin, G. Walther, C. Julien, S. Biron, S. Marceau, S. Lebel, F. Hould, L. Biertho, P. Poirier. Dichotomic Effect of Weight Loss Following Bariatric Surgery on QTc interval. «Obesity Summit», Kananaskis, AB, Canada. Appl.Physiol. Nutr. Metab.; 34:288, 2009. IF : 1.591 6 - J. Martin, G. Walther, S. Bergeron, J. Dumesnil, S. Biron, S. Marceau, S. Lebel, F. Hould, L. Biertho, O. Lescelleur, P. Poirier. Dysfonction diastolique ventriculaire gauche chez les obèses morbides : prévalence et impact d’une chirurgie bariatrique. Med.Sci. 25 (Suppl.1) :11, 2009. Congrès de la Société Québécoise d’HTA. IF : NA. 7 - J. Martin, G. Walther, S. Biron, S. Marceau, S. Lebel, F. Hould, P. Poirier. Normalization of diastolic function in morbidly obese patients after bariatric surgery. Canadian Cardiovascular Congress, Toronto, Canada, 2008. Can J Cardiol 24 (Suppl SE): 948, 2008. IF : 1.796 8 - G. Walther, S. Nottin, A. Pérez-Martin, M. Dauzat, P. Obert. Limb-specific vascular structure and function in elite athletes. Arch Mal Coeur Vaiss, 100, 2007. IF : 0.305 9 - G. Walther, G. Thöni, I. Schuster, S. Edérhy, S. Nottin, F. Boccara, A. Vinet, M. Khireddine, JM Mauboussin, I. Rouanet, A. Cohen, P. Messner-Pellenc, P. Obert and the Heart and Muscle Study Group/GECEM. Echocardiographic Assessment of Resting and Exercise Cardiac Function in Asymptomatic HIV-Infected 4

Patients under Antiretroviral Therapy. Arch Mal Coeur Vaiss, 99 ; p377, 2006. IF : 0.305 10 - G. Walther, S. Nottin, M. Dauzat, P. Obert. Evaluation des débits sanguins locaux des artères fémorale et axillaire à l’exercice par échographie Doppler. Arch Mal Coeur Vaiss, 98 ; p 420, 2005. IF : 0.305 11 - C. Reboul, S. Tanguy, G. Walther, S. Nottin, M. Dauzat, P.Obert. Implications of cardiac remodelling after altitude training in the limitation of maximal stroke volume increase and aerobic performance. Arch Mal Coeur Vaiss, 97; p 414, 2004. IF : 0.305 Conferences and posters published in the congress proceedings 1 – F. Dutheil, R. Chapier, B. Lesourd, D. Courteix, A. Fogli, G. Walther, A.Vinet, G. Lac. Influence of a combined program of physical activity and diet on atherogenic subfractions of LDL cholesterol in metabolic syndrome treatment. Congrès de la société de Physiologie (P2T), Dijon, France. 2 - J. Martin, G. Walther, C. Julien, S. Biron, S. Marceau, S. Lebel, F. Hould, L. Biertho, P. Poirier. Effet dichotomique d’une perte de poids induite par une chirurgie bariatrique sur l’intervalle QTc. 10e Congrès annuel de la Société québécoise de lipidologie, de nutrition et de métabolisme, Québec, Qc, Canada. 3 - G. Thöni, G. Walther, S. Nottin, A. Vinet, A. Varray, J. Mercier, P. Obert. Promoting physical activity in people living with HIV-infection: a new challenge for their health management in a lifelong perspective. 3rd Annual meeting of the WHO - European network for the promotion of health-enhancing physical activity (HEPA), Graz, Autriche, 2007. 4 - G. Walther, S. Nottin, A. Perez-Martin, M. Dauzat, P. Obert. Methodological approach of artery Doppler blood flow measurement during dynamic exercise. 11ème of the European College of Sports Science, Lausanne, Suisse, 2006. 5 - L. Karpoff, G. Walther, A. Perez-Martin, I. Shuster, P. Obert, A.Vinet. Impact de l’obésité infantile sur la fonction vasculaire au repos et au cours d’un exercice local. 4ème Congrès de Physiologie de l’exercice chez l’enfant, Clermont-Ferrand, France, 2006. Communication orale. 6 - G. Walther, L. Rasseneur, T. Rupp, J. Lonsdorfer. Cardiorespiratory responses to interval training. 11ème Congrès international de l’ACAPS, Paris, France, 2005. 7 - G. Walther, S. Nottin, M. Dauzat, P. Obert. Approche méthodologique de l’évaluation des débits sanguins à l’exercice par échographie Doppler. 3ème Congrès de Physiologie de l’exercice chez l’enfant, Avignon, France, 2004. Communication Orale. 8 - T. Rupp, L. Rasseneur, G. Walther, J. Lonsdorfer. Cardiorespiratory responses during badminton activity: effect of two point-counting methods. 10ème Congrès international de l’ACAPS, Toulouse, France, 2003. 9 - S. Cornus, G. Walther, T. Rupp, L. Rasseneur Perception affordance and maximal exercise testing. 10ème Congrès international de l’ACAPS. 30 octobre-1er novembre 2003. Toulouse, France. 10 - I. Schuster, G. Thöni, S. Edérhy, G. Walther, F. Boccara, M. Khireddine, S. Nottin, A. Vinet, JM Mauboussin, I. Rouanet, A. Cohen, P. Obert, P. Messner-Pellenc and the Heart and Muscle Study Group/GECEM. Diastolic and systolic function at rest and exercise in asymptomatic HIV-infected patients under antiretroviral therapy: need for systematic echocardiographic screening? European Society of Cardiology, Stockholm, Suède, 2005.

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CHAPTERS IN BOOKS 1 - S. Cornus, G. Walther, T. Rupp, L. Rasseneur. Perceiving of the obstacle step-acrossability after the maximal exercise test. Studies in Perception and Action XIII, 2005 Lawrence Erlbaum Associates, Inc. INVITED PRESENTATION 1 – Symposium, XII International Congress of the ACAPS, Leuven, Belgium, 2007, Title: Structural and functional vascular alterations in response to long-term intensive training. 2 – Symposium. Physiology Institute, Faculty of Medecine, Fribourg, Switzerland, 2007, Title: Evaluation of vascular structure and function adaptations consecutive to chronic exercise in health and disease. 3 – Symposium. Physiology & Physiopathology of Cardiovascular Adaptations to Exercise Lab, University of Avignon, France, 2009, Title: Amniotic stem cells : Perspectives for cellular therapy in cardiomyoplasty ; in vitro et in vivo studies. 4 - Symposium. Institute of Bioengineering, University of Miguel Hernandez, Elche, Spain, 2010, Title: Amniotic stem cells in cardiomyoplasty: From benchside to bedside.

GRANTS AND FUNDING 1. Arterial stiffness and vasomotion relates to mediacalcification in highly-trained athletes, French Society of Cardiology, France. PI : G. Walther. 15 000€. 2. Macro and microcirculation in obese children : implication of inflammation and oxidative stress, 2010-2011, French Society of Vascular Medecine, France. PI : A. Vinet, Co-I: G. Walther. 22 500€. 3. RESOLVE Study : Effects of exercise and nutritional program on bone, heart and muscle in metabolic syndrome, 2009-2010, Heart and Artery Foundation, France, PI: Lesourd B, Co-I: G. Walther. 235 000€. 4. Amniotic stem cells: bridge to heart transplantation, 2007-2008, Quebec Foundation for Health Research, Canada. PI: G. Walther. 90 000$. 5. Cardiovascular function and structure in highly-trained athletes, 2004-2007, University Hospital of Nimes, France, PI: G. Walther. 3 000€. 6. Effect of chronic exercise on cardiovascular function and structure in young and adult obese and diabetic subjects, 2004-2007, French Health Ministery, PI: Perez-Martin A, Co-I: G. Walther. 25 000€. 7. Functional adaptation in cardiac and skeletal muscle in HIV-infected patients receiving

highly

active

antiretroviral therapy, 2004-2006, ANRS, PI: Thöni G, Technical expertise funding: G. Walther, 58 000€.

INTERNATIONAL COLLABORATION - Pr. Paul POIRIER, FAHA, FACC, ACC, PhD, Heart and Lung Research Center, Hôpital Laval, Québec, CANADA . - Pr. Geraldine NAUGHTON, PhD, Director of the Centre of Physical Activity Across the Lifespan School of Exercise Science, Australian Catholic University, AUSTRALIA.

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- Pr. Jean-Pierre MONTANI, MD, PhD, Professor and Chair of Systems Physiology. Head of the Division of Physiology of the Dept. of Medicine, University of Fribourg, SWITZERLAND. - Pr. Enrique ROCHE, PhD, Chair of Institute of Bioengineering ,University Miguel Hernandez, University of Elche, SPAIN.

POST GRADUATE STUDENTS SUPERVISION - 2010 – present, David MONTERO, PhD student, supervisor (25%) University of Avignon, France and Uniersity of Elche, Spain. Title of thesis : Macro and microcirculation response in childhood obesity related to inflammation and oxidative stress. Impact of lifestyle intervention program. - 2007 – 2009, Julie MARTIN, PhD student, Supervisor (25%) University of Laval, Québec, Canada. Title of thesis: Metabolic and cardiovascular alteration of bariatric surgery in morbid obese patients. - 2005 – 2007, Lucie KARPOV, Master of Sciences, Physiology, Supervisor (50%) University of Avignon, France. Title of thesis: Muscle perfusion during exercise in obese children. - 2005 – 2007, Ronan BONIFAY, First year of Master of Sciences, Physiology, Supervisor (50%) University of Avignon, France. Title of thesis: Vascular alterations during exercise in old athletes.

TECHNICAL SKILLS Clinical research: - Structural and functional vascular wall exploration: intima-media thickness measurement, arterial compliance and distensibility, flow-mediated dilatation, nitroglycerin-mediated dilation with Ultrasound Doppler. - Microcirculation and cutaneous endothelial function with laser Doppler and iontophoresis. - Limb blood flow (muscle perfusion) measurements during exercise with Ultrasound Doppler. - Echocardiography: standard, tissue Doppler and speckle tracking imaging. - Heart rate variability analysed from “Holter” system. - Techniques of gas exchange during exercise by using the medical systems. - Transcoetaneous monitoring of muscle tissue: oxy- and deoxygenated hemoglobin and O2 saturation by near infrared spectroscopy. - Medical-physiological monitoring: anthropometric measurements and X-ray absorptiometry (Hologic), ECG at rest and exercise, tensonial profile at rest and during exercise, heart rate monitoring, detection of ventilatory thresholds.

Experimental research: - Blood subfractions isolations protocols (lymphocytes, neutrophiles, erythrocytes). - Cell culture: amniotic stem cells, embryonic stem cells, myoblasts. - Flow cytometry. - Cell immunomagnetic sorting. - Immunocytochemistry and immunohistochemistry.

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II. TEACHING Since 2003, I have been involved in teaching 425 hours during lectures, tutorial and practical classes from undergraduates to postgraduate levels in the School of Sport Sciences at the University of Avignon and at the School of Nursing in Avignon. Year

Amount of hours

2003-2004

68

2004-2005

82

2005-2006

96

2006-2007

96

2009-2010

83

Total

425

SUMMARY OF TEACHING ACTIVITY 2009-2010 Assistant Lecturer Avignon’s Hospital

School of Nursing (Amount of hours : 24) - General physiology

2009-2010 Casual Lecturer University of Avignon

School of Sport Sciences (Amount of hours : 96) - Exercise, health and diseases - General physiology - Statistic - Outdoor raid adventure (practice).

2006-2007 Assistant Lecturer University of Avignon

School of Sport Sciences (Amount of hours : 96) - Neurophysiology - Physiology of doping - Basket-ball (practice) - Statistic - Orientation trail (theory and practice).

2005-2006 Assistant Lecturer University of Avignon

School of Sport Sciences (Amount of hours : 96) - Introduction to biological science - Exercise testing and prescription (practice) - Fitness methodology - Energy cost in physical activities - Statistic and data processing - Orientation trail (theory and practice).

2004-2005 Casual Lecturer

School of Sport and Exercise Sciences (Amount of hours : 64 hours) - Methodology in biological science - Exercise testing and prescription (practice) - Methodology in physical preparation - Statistic - Thermoregulation and vascular physiology - Orientation trail (theory and practice).

2003-2004 Casual Lecturer

School of Sport and Exercise Sciences (Amount of hours : 75 hours) - General physiology - Data processing and statistic - Exercise testing and prescription (practice). 8

III. REFEREES Pr. Paul POIRIER, MD, PhD, FRCPC, FACC, FAHA Cardiologist / Head of the cardiac prevention/rehabilitation program Quebec Heart-Lung Institute Professor, Faculty of Medicine, Laval University Hôpital Laval 2725, chemin Sainte-Foy Québec G1V 4G5, Canada Phone : +1(418)6568711 Email : [email protected]

Pr. Philippe OBERT, PhD Head of Physiology and Physiopathology of Cardiovascular Adaptation to Exercise Laboratory EA4278 Laboratoire de Physiologie des Adaptations Cardiovasculaires à l'Exercice Faculté des Sciences, Université d'Avignon Pôle Sportif 84000 AVIGNON France Phone : +33(0)490162930 Email : [email protected]

Pr. Michel DAUZAT, MD, PhD Head of Research Laboratory EA 2992 – Montpellier-Nîmes University Head of Vascular Laboratory and Vascular Medicine, Nîmes University Hospital Centre Hospitalier Universitaire Carrémeau de Nîmes Place du Professeur Robert Debré 30029 NIMES France Phone : +33(0)466235538 Email : [email protected]

Dr. Olivier BERTRAND, MD, PhD Interventional Cardiologist Quebec Heart-Lung Institute Assistant-Professor, Faculty of Medicine, Laval University Hôpital Laval 2725, chemin Sainte-Foy Québec G1V 4G5, Canada Phone : +1(418)6568711 Email: [email protected]

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