CURRICULUM VITAE Name: Mauroy Surname: Benjamin Birth date: 10/10/1976 Marital status: Married, 2 children Email: [email protected] or [email protected] Website: http://benjamin.mauroy.free.fr Tel : +33 4.92.07.62.10 Fax : +33 4.93.51.79.74 Statut: CR1 CNRS HDR, i.e. 1st class Research Fellow for CNRS (French National Center for Scientific Research) in Laboratoire JA Dieudonné (Université de Nice Sophia-Antipolis, Parc Valrose, 06108 Nice cedex 2). Professional experience: 09/2010-...: Researcher for CNRS in laboratoire J.A. Dieudonné (Univ. Nice). - 2017-2021: principal investigator of the ANR VirtualChest (Défi Santé Bien-être) - 2016-…: initiator and head of the VADER Centre (Centre for VirtuAl modelling of rEspiRation), in the frame of the IDEX JEDI of Université Côte d’Azur. - 01/2015-05/2015: Visiting researcher in Auckland Bioengineering Institute (M.H. Tawhai’s team) - 15/12/2014: HDR (exam for official supervision of PhD thesis) - Teachings: supervision of final projects for Polytech'Nice (engineer school) in academic year 2013-2014 (22h) and 2015-20016 (11h). 2016-…: Master 1 MCS Nice (20h). 10/2005-09/2010: Researcher for CNRS in laboratoire Matières et Systèmes Complexes (Paris VII). Teachings: 09/2006-09/2010: Master 2 lectures and training for candidates to "Agrégation de Mathématiques”; 10/2005-09/2006: Training for Master 2 and for candidates to "Agrégation de Mathématiques". 09/2004-10/2005: Post-doc for CNRS in laboratoire J.L. Lions (Paris VI). Teachings: training for Master 2 and for candidates to "Agrégation de Mathématiques". 09/2000-09/2004: PhD thesis in Centre de Mathématiques et de Leurs Application in ENS de Cachan, supervised by B. Sapoval and L. Desvillettes, “Hydrodynamic in the lungs, interplays between flux and geometries”, defended on July the 5th 2004. Teachings: training for Master 2 and for candidates to "Agrégation de Mathématiques". 2000: Laureate of the "Agrégation de mathématiques". 1997-2001: Student in Ecole Normale Supérieure de Cachan, BSc and MSc in Mathematics. Research topics summary: My research aims at understanding how oxygen and carbon dioxide are transported and exchanged in mammals. I am looking for the underlying optimizations induced by evolution and constraints induced by physiology, such as developmental ones. My goal is to figure out how they affect the properties of the lungs, of the air/blood exchange surface and of the vascular network, with a specific focus on the geometries of these organs. More generally, my work aims to understand the role of physics on living systems, such as the role of fluids’ viscosity. My work involves deep interdisciplinary approaches and is based on the interplays between Mathematics, Biology, Medicine and Physics. I am developing mathematical and numerical models, with a multi-scale approach: from the organ size (such as bronchi) towards the cell (such as red blood cells). I study the robustness of the optimal strategies using population dynamics models and dynamic systems theory in the frame of Darwinian medicine. I also use and adapt these models for the study of the biophysics of the respiratory system in a medical frame, and more particularly in the frame of chest physiotherapy. My research is based on partial derivative equations, their properties (fluid mechanics, fluid-structure interaction, reaction-diffusion), optimization theory, dynamical systems and scientific computing. Supervision: Training: - eight Master students: “Mechanical chest physiotherapy: optimization of HFCWO” (M2, 2017), “Modelling of the propagation of an infection in the lung” (M2, 2017), “A numerical model for the

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modelling of an inhomogeneous distal bronchial tree” (M1, 2016), “Modelling of mucus flow in a bronchus and in a bifurcation” (M1, 2016), "Modelling of the motion of a periodic train of red blood cells in a capillary, energetic aspects" (M1, 2012), "Shape optimization of a bronchial bifurcation” (M2, 2011), "Modelling of the sedimentation of a red blood cell" (M1, 2008), "Towards the modelling of the vascular network" (M2, 2007) - three engineer school projects (Polytech’Nice, two in 2014, 2016) PhD Thesis: - 2016-…, supervision of the PhD thesis of J. Stephano, “Role of natural selection on the transport properties of oxygen and carbon dioxide transport in mammals”. - 2008-2012, supervision of the PhD thesis of B. Moreau (MSC, Paris 7), "Optimization of oxygen transport in the arterial microcirculation". - September 2008 to June 2011, participation to the supervision of the PhD thesis of P. Bokov (MSC, University Paris 7). - From June 2007 to October 2008, participation to the supervision of the PhD thesis of Y. Privat (IECN Nancy). Researchers: - Supervision of a post-doc, Mongkolsery Lin, from August 2015 to January 2016 (EMMA exchange program) on the topic of "dynamics of mucus in a smooth bronchus". - Supervision of a research engineer from the private company RespInnovation, Samir Rachidi, from September 2012 to January 2014, in the frame of a research contract on the topic "Modelling of respiratory physiotherapy". - Supervision of a post-doc, Raphaël Clément, from May 2011 to December 2013 (funded by Nice University and the city of Nice) on the topic "Lung's morphogenesis". Fundings: 2017-2021: Principal investigator (PI) of the ANR VirtualChest (Défi Santé Bien-être, 440k) 2016-…: initiator and head of the VADER Centre (Centre for VirtuAl modelling of rEspiRation), in the frame of the IDEX JEDI of Université Côte d’Azur (initial founding of 280k for four years). 2016: GDRI funding for developing a collaboration with Yeugnam University in South Korea (1.8 k) 2016: IDEX JEDI support for my project "modelling of chest physiotherapy" through the Academy Complex Systems (25k). 2016: PI of the PEPS INSIS "Modélisation de la kinésithérapie respiratoire : mise en réseau" (7k) 2015-2016: PI of the PEPS CNRS InPhyniti, Projet Structurant, project "Influence de la géométrie des bronches pulmonaires sur les écoulements d’air et de mucus" (2015: 15k, 2016:10k) 2014: PI of the PEPS CNRS, INSIS, frame Biological Flows, project "Modelling of respiratory physiotherapy" (10k). 2013: PI of the PEPS CNRS, frame Physique Théorique et Interfaces (PTI), project "Morphogenesis of the bronchial vascular network" (4k) 2012-2015: PI of a research contract with the company RespInnovation (Sophia Antipolis), project "Respiratory physiotherapy modekling" (15k). 2012: PI of the PEPS PTI "Morphogenesis of the bronchial vascular network" (3k). 2012-2013: 24 months post-doctoral support from the city of Nice, project "Lung's morphogenesis". 2011: Management of the funding for the development of a biology and mathematics hub in Nice (90k) 2010: PI of the modelling part of an interdisciplinary project (clinic/modelling) Inserm/DHOS, project "Polytrac" (10k) 2008-2011: Funding for a PhD thesis from the CNRS on the project "Arterial network hematocrit optimization". 2005-2009: Member of the ANR funding "Transport and transfer through the human pulmonary system" (12k). Other responsibilities and professional experience: In the comue Université Côte d’Azur: - Head of the Center for Virtual Modelling of Respiration (VADER center) in Université Côte d’Azur. - Member of the steering committee of the IDEX JEDI federative program “Modélisation, Physique et

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Mathématique du vivant”. - Member of the committee of the academy “Living systems Complexity and Diversity” of Université Côte d’Azur. In University de Nice-Sophia Antipolis: - Member of the scientific committee of the PhysBio axis in University Nice-Sophia Antipolis. - Elected member of the “Commission Permanente de Ressources Humaines” (Nice University commission in charge of recruitment). In laboratoire JA Dieudonné: - Representative of the interactions between Mathematics and Biology/Medicine in laboratoire JA Dieudonné. - Co-organisation of the Interfaces team seminar in laboratoire JA Dieudonné. - Member of two commissions in laboratoire JA Dieudonné (role of the commissions: lab. financial support for interdisciplinary projects; lab. financial support for master and PhD students). - Member of the scientific committee of the CNRS Research Group 2760 (fluid-structure interaction) from 2008 to 2012. - Local correspondent of the CNRS Research Group METICE in Nice (2013-...) - Local correspondent of the CNRS Research Group GDR MECABIO in Nice (2012-...) Other: - Conferences co-organisation: PhysBio days in Nice (sept. 2015, dec. 2015, jan. 2016) Bio-Phys-Maths 2nd edition meeting in Nice (December 11-13, 2013). Bio-Phys-Maths meeting in Nice (November 21-23, 2011). IMREDD Doct. meeting "Modeling for environment and health" in Nice (Oct. 8-10, 2012). - Member of the jury for Applied Mathematics Assistant Professor positions (one in Toulouse in 2012, two in Nice in 2011, one in Paris in 2009). - Member of the jury in three PhD thesis defence. - Reviewer for two PhD theses (one from Auckland Bioenginnering Institute). - Reviewer for journals in mathematics, fluid mechanics, biophysics. - Reviewer of a project for NSERC-CRSNG (Canada). Popularisation: - Popularisation talk (high school, general public), "Poumon, paratonnerres et mathématiques", Valrose, Nice, June 2013. - Publication of a popularisation paper in the journal "La Recherche" in 2005, republished in "La Recherche" in 2007 and in the book "Débusquer le hasard" (La Recherche-Dunod, 2011). - Introduction of the Mathematics to elementary school children in the frame of "Science feast" (CNRS délégation Paris A). - Posters realisation ("What are the mathematics?") for the science museum "Palais de la Découverte" in Paris, in collaboration with C. Baranger, L. Baudouin and V. Roussier. Awards: Sept. 2004: Award from the Pneumology Professor College in France. Nov. 2005: Prize La Recherche 2005, Research Ministry mention (with M. Felici, M. Filoche, B. Sapoval and E.R Weibel). Publications & conferences: http://benjamin.mauroy.free.fr/divers/publis.pdf

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