THE JOURNALOF B I O ~ I CCHEMISTRY AL

Vol. 269, No. 9. Issue of March 4, pp. 6664-6670, 1994 Printed in U S A

0 1994 by The American Society for Biochemistry and Molecular Biology, Inc

Transcriptional Modulation by n-Butyric AcidPl-, of P2-, and P3-Adrenergic Receptor Balancein 3T3-F442A Adipocytes* (Received for publication,July 30, 1993, and in revised form, October 1, 1993)

St6phane KriefSs, Bruno FBvex B6atrice BaudeS, Vladimir ZilberfarbS, A. DOMY StrosbergSII, Jacques Pairaultll, and Lament J. EmorineSs From the $Centre National de la Recherche Scientifique Unite Propre de Recherche 0415 and Universitd Paris VZZ, Znstitut Cochin de C2dtique Moleculaire, 22 rue Mdchain, 75014-Paris, France and the Wnstitut National de la Sante et de la Recherche Mddicale Unite 282, H6pital Henri Mondor, 94010-Creteil, France

3T3-F442A adipocytes, which express major pS-adre- system. Induction of the 0-AR’ by butyrate, initially described nergic receptors (p3-AR) (90%) and minor p1-m (