Chemical Physics Letters 393 (2004) 442–447 www.elsevier.com/locate/cplett
Sensitization of 5-bromouridine by slow electrons Hassan Abdoul-Carime
a,*
, Paulo Lima˜o-Vieira b,c, Sascha Gohlke a, Irina Petrushko a, Nigel J. Mason d, Eugen Illenberger a
a
d
Institut fu¨r Chemie – Physikalische und Theoretische Chemie, Freie Universita¨t Berlin, Takustrasse 3, D-14195 Berlin, Germany b Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, UK c Departamento de Fı´sica, CeFITec, FCT – Universidade Nova de Lisboa, Quinta da Torre, P-2829-516 Caparica, Portugal Departament of Physics and Astronomy, Centre of Molecular and Optical Sciences, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK Received 23 May 2004; in final form 16 June 2004 Available online 7 July 2004
Abstract Substitution of thymidine by 5-bromouridine within DNA sensitizes the nucleic acid to radiation. We show here the ability of low-energy (ls), since any reaction requires a high activation energy. In contrast to that, ballistic low-energy (
