May 10, 2013 - Key Note Lecture: Pr. Annika Keller (Zurich, Switzerland). âPericytes - gatekeepers at the neurovascular unitâ. 9:35 am Session âBlood-brain ...
Opening of the Meeting: JF Ghersi-Egea, R Cecchelli
2:20 pm Key Note Lecture: Pr. Colin Green (University of Auckland, New Zealand) “Gap Junction Hemichannel Roles in Neuroinflammation and Vascular Leak“ 3:10 pm
Session “Blood Brain Barriers and Diseases” Chaired by Luc Leybaert and Peter Brown
3:15 pm
Julien Saint Pol: Oxysterols, Liver X Receptors (LXRs) & Alzheimer’s Disease : focus at the Blood-Brain Barrier (BBB) level
3:45 pm
Camilla Cerutti: MicroRNA-126 and microRNA-126*: two new players in flowbased leukocyte adhesion on cytokine-activated human brain endothelium in vitro
Roosmarijn Vandenbroucke: Identification of new therapeutic targets to prevent epithelial blood-CSF barrier disruption in systemic inflammatory disorders and (inflamm)aging
5:35 pm
Elodie Vandenhaute: Transmigration of neuroblastoma cancer cells through the blood-cerebrospinal fluid barrier in vitro and its modulation by fractalkine (CX3CL1) chemokine
6:05 pm
Poster Session
6:45 pm
General Meeting of the SEISC and Free Evening
Thursday, May 16 8:45 am Key Note Lecture: Pr. Jean-Michel Scherrmann (Paris, France) “Targeting the Brain: Hot Air or Hot Stuff” 9:35 am
Session “Brain Drug Delivery and Transporters” Chaired by Pierre-Olivier Couraud and Pierre-Emmanuel Ceccaldi
9:40 am
Gavin Fullston: Modelling the Transport of Nanoparticles across the Blood-Brain Barrier
10:10am
Kathryn Ball: An in vitro-based PBPK model for prediction of BBB permeability and unbound brain concentrations of drugs
10:40 am
Coffee break
11: 00 am
Hélène Chapy: Functional studies of a new xenobiotic transporter also called « clonidine transporter »: in vivo and in vitro approaches
11:30 am
Radka Gromnicova: Glucose-coated gold nanoparticle: a potential carrier across the blood-brain barrier
12:00 am
Commercial presentation by Eppendorf Society (please register at registration desk if you wish to attend this conference)
12:45 am
Lunch
2:00 pm
Session “Barrier Signaling and regulation of brain fluids” Chaired by Roosmarijn Vandenbroucke and Marie-Pierre Dehouck
2:05 pm
Kayathiri Ganeshamoorthy: Laminar shear stress enhances blood brain properties of a human adult brain endothelial cell line (hCMEC/D3)
barrier
2:35 pm
Cédric Artus: The Wnt/Planar Cell Polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells
2:55 pm
Marie O’Connor: Regional heterogeneity in the endothelial glycocalyx and basement membrane of the retinal vasculature
3:25 pm
Coffee Break
3:55 pm
Fanny Langlet: Blood-cerebrospinal fluid barrier in CNS control of feed
4:25 pm
Peter Brown: Functional studies of NBCe2 (SLC4A5) in choroid plexus epithelial cells
4:55 pm
Poster session
7:30 pm
Gala Dinner at Restaurant LE CARNOT 10/12 Place Foch - 62000 ARRAS, just in front of the railway station
Friday, May 17 8:45 am Key Note Lecture: Pr. Annika Keller (Zurich, Switzerland) “Pericytes - gatekeepers at the neurovascular unit” 9:35 am
Session “Blood-brain barriers in the developing brain” Chaired by John Greenwood and Jean-François Ghersi-Egea
9:40 am
Ingrid Kratzer: Tight junction proteins, detoxifying enzymes, and efflux transporters in choroid plexus and ependyma contribute to neuroprotection during development
10:10 am
Stijn Van Herck: Expression of thyroid hormone transporters and deiodinases at the brain-barriers during chicken embryonic development.
10:40 am
Coffee break
11:00 am
Karelle Benardais: Long-term consequences of perinatal inflammation on the blood-brain barrier structure and on the course of de- and remyelination in the central nervous system
11:30 am:
Marie-Pierre Dehouck: A human blood-brain barrier model derived from stem cells
12:00 am:
Closing remarks: Marie-Pierre Dehouck
12:10 pm:
Final discussions in front of the posters
13:00 pm
End of the Meeting
Afternoon:
Visit of Arras (Fine Arts Museum) and Louvre-Lens Museum for those who are interested.
Poster Session Cédric Artus: The Wnt/Planar Cell Polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells Raj Badhan: The influence of heterogenous, regional drug-brain tissue binding on drug disposition and pharmacokinetics across the central nervous system Catarina Chaves: Effect of the opioid subchronic exposure and withdrawal in the modulation of biomarkers of the blood-brain barrier Caroline Coisne : Claudin-3 and claudin-5 functions at the Blood-Brain Barrier Martine Cohen-Salmon: Deletion of astroglial connexins weakens the blood-brain barrier Marijke De Bock: The endotoxin LPS induces an inflammatory response and increase in bloodbrain barrier permeability that involves intracellular Ca2+ changes Delphine Demeestere: Importance of the blood-CSF barrier in systemic inflammation Céline Dinocourt: Uranium and the brain: a long history … but not ended Aurore Drolez : Breast cancer cells metastasis to the brain: a preliminary approach using a new human in vitro BBB model Anaelle Fabulas - da Costa: Repeated dose toxicity of colchicine in an in vitro blood-brain barrier model Kayathiri Ganeshamoorthy: Laminar shear stress enhances blood-brain barrier properties of a human adult brain endothelial cell line (hCMEC/D3) Alice Gaudin : Passage of nucleoside analogues accross the Blood-Brain Barrier using squalenoyl nanovectors Mélanie Kuntz: Transient opening of the Blood-Brain Barrier following Oxygen-Glucose Deprivation sensitizes endothelial cells to acute administration of tPA at 4h of reoxygenation. Mohd Hamzah Nasir: Potential mechanisms underlying the increase in permeability of the BBB in the cerebral malaria Abraham Sabu: Regulation of blood vessel function by Apelin signaling Gayathri N. Sekhar: Investigating eflornithine transport at the human blood-brain barrier using hCMEC/D3 as a model; focus on cationic amino acid transporters. Emmanuel Sevin: A human blood-brain barrier model derived from stem cells
