Randomised controlled trial of streptokinase, aspirin ... - Science Direct
streptokinase plus aspirin had a significantly higher risk of early death than those given neither streptokinase nor aspirin (odds ratio 3·5; 95% Cl ...
Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke Multicentre Acute Stroke
Trial—Italy (MAST-I) Group*
Summary
Introduction
ischaemic stroke, thrombolytic drugs speed the recanalisation of intracerebral arteries. The effects of aspirin are not known. A trial was conducted to determine whether, separately or together, streptokinase and aspirin have clinical benefits in acute ischaemic stroke similar to those in acute myocardial infarction. 622 patients with acute ischaemic stroke within 6 hours of symptom onset were randomised with a 2x2 factorial design to (i) a 1-hour intravenous infusion of 1·5 MU streptokinase, (ii) 300 mg/day buffered aspirin for 10 days, (iii) both active treatments, or (iv) neither. Early results raised a question whether the trial should be continued. Streptokinase (alone or with aspirin) was associated with an excess of 10-day case fatality (odds ratio 2·7; 95% Of the four confidence interval 1·7-4·3; 2p
tissue-type plasminogen activator) in acute ischaemic stroke has been investigated in two trials. The National. Institute of Neurological Disorders and Stroke.
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