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Liste de publications de Laurence Van Melderen 5.1.3. - Parties d'ouvrages collectifs 2015 1.

Goormaghtigh, F., & Van Melderen, L. (2015). Setting up a Reproducible Method for Measuring Persistence in a Growing E. coli Population. In Bacterial persistence.

2012 2.

Deghorain, M., Goeders, N., Jove, T., & Van Melderen, L. (2012). Type II toxinantitoxin loci: the ccdAB and ParDE families. In Prokaryotic toxin-antitoxin loci. doi:10.1007/978-3-642-33253-1_4

2010 3.

Aertsen, A., De Spiegeleer, P. P., Van Melderen, L., & Michiels, C. C. (2010). General Stress Response of a Model Bacterium. In Plant Stress Biology: From Genomics to Systems Biology. doi:10.1002/9783527628964.ch1

2002 4.

Szpirer, C., Gabant, P., & Van Melderen, L. (2002). Plasmid poison/antidote systems: functions and technological applications. In Recent research Developments in Plasmid Biology.

5.1.4. et 5.1.5. - Articles dans des revues scientifiques avec comité de lecture 2015 1.

Wessner, F. F., Lacoux, C. C., Goeders, N., Fouquier d'Hérouel, A. A., Matos, R. R., Serror, P. P., Van Melderen, L., & Repoila, F. F. (2015). Regulatory crosstalk between type I and type II toxin-antitoxin systems in the human pathogen Enterococcus faecalis. RNA biology, 12(10), 1099-1108. doi:10.1080/15476286.2015.1084465

2014 2.

Sanderson-Smith, M. L., De Oliveira, D. M. P., Guglielmini, J., McMillan, D. J., Vu, T., Holien, J. K., Henningham, A., Steer, A. C., Bessen, D. E., Dale, J. B., Curtis, N., Beall, B. W., Walker, M. J., Parker, M. W., Carapetis, J. R., Van Melderen, L., Sriprakash, K. S., Smeesters, P., & the M Protein Study Group, (2014, octobre). A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. The Journal of infectious diseases, 210(8), 1325-1338. doi:10.1093/infdis/jiu260

3.

Sterckx, Y., Haesaerts, S., Van Melderen, L., & Loris, R. (2014, août). Crystallization and preliminary X-ray analysis of two variants of the Escherichia coli O157 ParE2-PaaA2 toxinantitoxin complex. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, 70(9), 1284-1291. doi:10.1107/S2053230X1401749X

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-4.

Sterckx, Y., Volkov, A. A., Vranken, W., Kragelj, J. J., Jensen, M. R. M., Buts, L., GarciaPino, A., Jove, T., Van Melderen, L., Blackledge, M. M., van Nuland, N. A. J., & Loris, R. (2014, juin). Small-angle X-ray scattering- and nuclear magnetic resonance-derived conformational ensemble of the highly flexible antitoxin PaaA2. Structure, 22(6), 854-865. doi:10.1016/j.str.2014.03.012

5.

Sterckx, Y. G. J., Volkov, A., Vranken, W. F., Kragelji, J., Jensen, M., Buts, L., GarciaPino, A., Jove, T., Van Melderen, L., Blackledge, M., van Nuland, N. A. J., & Loris, R. (2014, avril 23). Small-Angle X-Ray Scattering- and Nuclear Magnetic Resonance-Derived Conformational Ensemble of the Highly Flexible Antitoxin PaaA2. Structure.

6.

Goeders, N., & Van Melderen, L. (2014, janvier). Toxin-antitoxin systems as multilevel interaction systems. Toxins, 6(1), 304-324. doi:10.3390/toxins6010304

2013 7.

Vercammen, K., Garcia Armisen, T., Goeders, N., Van Melderen, L., Bodilis, J., & Cornelis, P. (2013, août). Identification of a metagenomic gene cluster containing a new class A beta-lactamase and toxin-antitoxin systems. MicrobiologyOpen, 2(4), 674-683. doi:10.1002/mbo3.104

8.

Van Houdt, R., Deghorain, M., Vermeersch, M., Provoost, A., Lo Giudice, A., Leys, N., Perez-Morga, D., Van Melderen, L., & Michaud, L. (2013, juillet). Characterization of culturable Paenibacillus spp. from the snow surface on the high Antarctic Plateau (DOME C) and their dissemination in the Concordia research station. Extremophiles, 17(4), 565-573. doi:10.1007/s00792-013-0539-3

9.

Goeders, N., Dreze, P. L., & Van Melderen, L. (2013, juin). Relaxed cleavage specificity within the RelE toxin family. Journal of bacteriology, 195(11), 2541-2549. doi:10.1128/ JB.02266-12

10.

Guérout, A.-M., Iqbal, N., Mine, N., Ducos-Galand, M., Van Melderen, L., & Mazel, D. (2013, mai). Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons. Journal of bacteriology, 195(10), 2270-2283. doi:10.1128/JB.01389-12

11.

Seyll, E., & Van Melderen, L. (2013). The ribonucleoprotein Csr network. International journal of molecular sciences, 14(11), 22117-22131. doi:10.3390/ijms141122117

12.

Peris-Bondia, F., Muraille, E., & Van Melderen, L. (2013). Complete Genome Sequence of the Escherichia coli PMV-1 Strain, a Model Extraintestinal Pathogenic E. coli Strain Used for Host-Pathogen Interaction Studies. Genome announcements, 1(5). doi:10.1128/ genomeA.00913-13

2012 13.

Vandevoorde, A., Ascenzo, S., Miendjé Deyi, V. Y., Mascart, G., Mansbach, A.-L., Landsberg, M., Drèze, P., Steer, A. C., Van Melderen, L., & Smeesters, P. (2012, décembre). Group A Streptococcus Colonies from a Single Throat Swab Can Have Heterogeneous Antimicrobial Susceptibility Patterns. The Pediatric infectious disease journal. doi:10.1097/INF.0b013e31827c9796

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-14. Deghorain, M., & Van Melderen, L. (2012, décembre). The Staphylococci phages family: an overview. Viruses, 4(12), 3316-3335. 15.

McMillan, D. J., Drèze, P.-A., Vu, T., Bessen, D. E., Guglielmini, J., Steer, A. C., Carapetis, J. R., Van Melderen, L., Sriprakash, K. S., & Smeesters, P. (2012, décembre). Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study. Clinical microbiology and infection. doi:10.1111/1469-0691.12134

16.

Deghorain, M., Bobay, L.-M., Smeesters, P., Bousbata, S., Vermeersch, M., Perez-Morga, D., Drèze, P.-A., Rocha, E. P. C., Touchon, M., & Van Melderen, L. (2012, novembre). Characterization of Novel Phages Isolated in Coagulase-Negative Staphylococci Reveals Evolutionary Relationships with Staphylococcus aureus Phages. Journal of bacteriology, 194(21), 5829-5839. doi:10.1128/JB.01085-12

17.

Van Melderen, L. (2012, octobre). GhoSTly bacterial persisters. Nature Chemical Biology, 8(10), 812-813. doi:10.1038/nchembio.1066

18.

Jourdain, S., Drèze, P.-A., Verhaegen, J., Van Melderen, L., & Smeesters, P. (2012, septembre). Carriage-Associated Streptocccus pneumoniae Serotype 1 in Brussels, Belgium. The Pediatric infectious disease journal. doi:10.1097/INF.0b013e3182755cb7

19.

Sterckx, Y. G. J., Garcia-Pino, A., Haesaerts, S., Jove, T., Geerts, L., Sakellaris, V., Van Melderen, L., & Loris, R. (2012, juin). The ParE2-PaaA2 toxin-antitoxin complex from Escherichia coli O157 forms a heterodocecamer in solution and in the crystal. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, 68(Pt 6), 724-729. doi:10.1107/S1744309112015230

20.

Retamal Reyes, C., Dewasme, L. L., Hantson, A. L. A., Vande Wouwer, A. A., Timmermans, J., & Van Melderen, L. (2012). Investigation of the effect of a genetic manipulation through macroscopic dynamic modeling. IFAC proceedings volumes, 172-177. doi:10.3182/20120829-3-HU-2029.00072

2011 21.

Guglielmini, J., & Van Melderen, L. (2011, novembre). Bacterial toxin-antitoxin systems: Translation inhibitors everywhere. Mobile genetic elements, 1(4), 283-290. doi:10.4161/ mge.18477

22.

Hayes, F., & Van Melderen, L. (2011, octobre). Toxins-antitoxins: diversity, evolution and function. Critical reviews in biochemistry and molecular biology, 46(5), 386-408. doi:10.3109/10409238.2011.600437

23.

Tesfazgi Mebrhatu, M., Wywial, E., Ghosh, A., Michiels, C. W., Lindner, A. B., Taddei, F., Bujnicki, J. M., Van Melderen, L., & Aertsen, A. (2011, août). Evidence for an evolutionary antagonism between Mrr and Type III modification systems. Nucleic acids research, 39(14), 5991-6001. doi:10.1093/nar/gkr219

24.

Leplae, R., Geeraerts, D., Hallez, R., Guglielmini, J., Drèze, P., & Van Melderen, L. (2011, juillet). Diversity of bacterial type II toxin-antitoxin systems: a comprehensive search and functional analysis of novel families. Nucleic acids research, 39(13), 5513-5525. doi:10.1093/nar/gkr131

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-25. Jourdain, S., Smeesters, P., Denis, O., Dramaix Wilmet, M., Sputael, V., Malaviolle, X., Van Melderen, L., & Vergison, A. (2011, juin). Differences in nasopharyngeal bacterial carriage in preschool children from different socio-economic origins. Clinical microbiology and infection, 17(6), 907-914. doi:10.1111/j.1469-0691.2010.03410.x 26.

Smeesters, P., Drèze, P.-A., Bousbata, S., Parikka, K. J., Timmery, S., Hu, X., PerezMorga, D., Deghorain, M., Toussaint, A., Mahillon, J., & Van Melderen, L. (2011, mai). Characterization of a novel temperate phage originating from a cereulide-producing Bacillus cereus strain. Research in microbiology, 162(4), 446-459. doi:10.1016/ j.resmic.2011.02.009

27.

Jourdain, S., Drèze, P.-A., Vandeven, J., Verhaegen, J., Van Melderen, L., & Smeesters, P. (2011). Sequential multiplex PCR assay for determining capsular serotypes of colonizing S. pneumoniae. BMC infectious diseases, 11, 100. doi:10.1186/1471-2334-11-100

2010 28.

Van Melderen, L. (2010, décembre). Toxin-antitoxin systems: why so many, what for? Current opinion in microbiology, 13(6), 781-785. doi:10.1016/j.mib.2010.10.006

29.

Smeesters, P., Cadar, S., Drèze, P.-A., Campos, D., & Van Melderen, L. (2010, novembre). Polyclonal dissemination of tetracycline resistance among Streptococcus pyogenes paediatric isolates from Brazil. Journal of Infection in Developing Countries, 4(11), 704-711.

30.

Hallez, R., Geeraerts, D., Sterckx, Y., Mine, N., Loris, R., & Van Melderen, L. (2010, mai). New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7. Molecular microbiology, 76(3), 719-732. doi:10.1111/ j.1365-2958.2010.07129.x

31.

Timmermans, J., & Van Melderen, L. (2010, mai). Post-transcriptional global regulation by CsrA in bacteria. Cellular and molecular life sciences. doi:10.1007/s00018-010-0381-z

32.

Sablier, F., Slaouti, T., Drèze, P.-A., Fouly, P., Allemeersch, D., Van Melderen, L., & Smeesters, P. (2010, mars 20). Nosocomial transmission of necrotising fasciitis. Lancet, 375(9), 1052. doi:10.1016/S0140-6736(10)60052-9

33.

Smeesters, P., Dramaix Wilmet, M., & Van Melderen, L. (2010, janvier). The emmtype diversity does not always reflect the M protein genetic diversity--is there a case for designer vaccine against GAS. Vaccine, 28(4), 883-885. doi:10.1016/ j.vaccine.2009.10.137

2009 34.

Van Melderen, L., & Aertsen, A. (2009, novembre). Regulation and quality control by Lon-dependent proteolysis. Research in microbiology, 160(9), 645-651. doi:10.1016/ j.resmic.2009.08.021

35.

Smeesters, P., Drèze, P.-A., Perez-Morga, D., Biarent, D., Van Melderen, L., & Vergison, A. (2009, octobre). Group A Streptococcus virulence and host factors in two toddlers

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with rheumatic fever following toxic shock syndrome. International journal of infectious diseases, 14, 403-409. doi:10.1016/j.ijid.2009.06.025

36.

Smeesters, P., Vergison, A., Junior, D. C., & Van Melderen, L. (2009, juillet). Emerging fluoroquinolone-non-susceptible group A streptococci in two different paediatric populations. International journal of antimicrobial agents, 34(1), 44-49. doi:10.1016/ j.ijantimicag.2009.01.012

37.

Respondek, M., Buts, L., De Jonge, N., Haesaerts, S., Loris, R., Van Melderen, L., Wyns, L., & Zangger, K. (2009, juin). Sequence-specific 1H, 15N and 13C resonance assignments of the 23.7-kDa homodimeric toxin CcdB from Vibrio fischeri. Biomolecular NMR assignments, 3(1), 145-147. doi:10.1007/s12104-009-9161-9

38.

Mine, N., Guglielmini, J., Wilbaux, M., & Van Melderen, L. (2009, avril). The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species. Genetics, 181(4), 1557-1566. doi:10.1534/genetics.108.095190

39.

Timmermans, J., & Van Melderen, L. (2009, mars). Conditional essentiality of the csrA gene in Escherichia coli. Journal of bacteriology, 191(5), 1722-1724. doi:10.1128/ JB.01573-08

40.

Van Melderen, L., & Saavedra De Bast, M. (2009, mars). Bacterial toxin-antitoxin systems: more than selfish entities? PLoS genetics, 5(3), e1000437. doi:10.1371/ journal.pgen.1000437

2008 41.

Smeesters, P., Mardulyn, P., Vergison, A., Leplae, R., & Van Melderen, L. (2008, octobre). Genetic diversity of Group A Streptococcus M protein: implications for typing and vaccine development. Vaccine, 26(46), 5835-5842. doi:10.1016/j.vaccine.2008.08.037

42.

Saavedra De Bast, M., Mine, N., & Van Melderen, L. (2008, juillet). Chromosomal toxinantitoxin systems may act as antiaddiction modules. Journal of bacteriology, 190(13), 4603-4609. doi:10.1128/JB.00357-08

2007 43.

Tsilibaris, V., Maenhaut-Michel, G., Mine, N., & Van Melderen, L. (2007, septembre). What is the benefit to Escherichia coli of having multiple toxin-antitoxin systems in its genome? Journal of bacteriology, 189(17), 6101-6108. doi:10.1128/JB.00527-07

44.

Wilbaux, M., Mine, N., Guérout, A.-M., Mazel, D., & Van Melderen, L. (2007, avril). Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7. Journal of bacteriology, 189(7), 2712-2719. doi:10.1128/ JB.01679-06

45.

De Jonge, N., Buts, L., Vangelooven, J., Mine, N., Van Melderen, L., Wyns, L., & Loris, R. (2007, avril). Purification and crystallization of Vibrio fischeri CcdB and its complexes with fragments of gyrase and CcdA. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, 63(Pt 4), 356-360. doi:10.1107/ S1744309107012092

2006

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-46. Smeesters, P., Campos, D., Van Melderen, L., de Aguiar, E., Vanderpas, J.-B., & Vergison, A. (2006, décembre). Pharyngitis in low-resources settings: a pragmatic clinical approach to reduce unnecessary antibiotic use. Pediatrics, 118(6), e1607-e1611. doi:10.1542/peds.2006-1025 47.

Madl, T., Van Melderen, L., Mine, N., Respondek, M., Oberer, M., Keller, W., Khatai, L., & Zangger, K. (2006, novembre). Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA. Journal of Molecular Biology, 364(2), 170-185. doi:10.1016/ j.jmb.2006.08.082

48.

Tsilibaris, V., Maenhaut, G., & Van Melderen, L. (2006, octobre). Biological roles of the Lon ATP-dependent protease. Research in microbiology, 157(8), 701-713. doi:10.1016/ j.resmic.2006.05.004

49.

Smeesters, P., Vergison, A., Campos, D., de Aguiar, E., Miendjé Deyi, V. Y., & Van Melderen, L. (2006). Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape. PloS one, 1, e10. doi:10.1371/journal.pone.0000010

50.

Aguirre-Ramírez, M., Ramírez-Santos, J., Van Melderen, L., & Gómez-Eichelmann, M. C. (2006, janvier). Expression of the F plasmid ccd toxin-antitoxin system in Escherichia coli cells under nutritional stress. Canadian journal of microbiology, 52(1), 24-30. doi:10.1139/ w05-107

2005 51.

Dao-Thi, M.-H., Van Melderen, L., De Genst, E., Afif, H., Buts, L., Wyns, L., & Loris, R. (2005, mai). Molecular basis of gyrase poisoning by the addiction toxin CcdB. Journal of Molecular Biology, 348(5), 1091-1102. doi:10.1016/j.jmb.2005.03.049

2004 52.

Dao-Thi, M.-H., Van Melderen, L., De Genst, E., Buts, L., Ranquin, A., Wyns, L., & Loris, R. (2004, juin). Crystallization of CcdB in complex with a GyrA fragment. Acta crystallographica. Section D, Biological crystallography, 60(Pt 6), 1132-1134. doi:10.1107/ S0907444904007814

53.

Christensen, S. K., Maenhaut-Michel, G., Mine, N., Gottesman, S., Gerdes, K., & Van Melderen, L. (2004, mars). Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system. Molecular microbiology, 51(6), 1705-1717. doi:10.1046/j.1365-2958.2003.03941.x

2002 54.

Allali, N., Afif, H., Couturier, M., & Van Melderen, L. (2002, juin). The highly conserved TldD and TldE proteins of Escherichia coli are involved in microcin B17 processing and in CcdA degradation. Journal of bacteriology, 184(12), 3224-3231. doi:10.1128/ JB.184.12.3224-3231.2002

55.

Van Melderen, L. (2002, février). Molecular interactions of the CcdB poison with its bacterial target, the DNA gyrase. International journal of medical microbiology, 291(6-7), 537-544.

2001

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-56. Afif, H., Allali, N., Couturier, M., & Van Melderen, L. (2001, juillet). The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison-antidote system. Molecular microbiology, 41(1), 73-82. doi:10.1046/j.1365-2958.2001.02492.x 1999 57.

Van Melderen, L., & Gottesman, S. (1999, mai). Substrate sequestration by a proteolytically inactive Lon mutant. Proceedings of the National Academy of Sciences of the United States of America, 96(11), 6064-6071. doi:10.1073/pnas.96.11.6064

58.

Loris, R., Dao-Thi, M.-H., Bahassi, E. M., Van Melderen, L., Poortmans, F., Liddington, R., Couturier, M., & Wyns, L. (1999, janvier). Crystal structure of CcdB, a topoisomerase poison from E. coli. Journal of Molecular Biology, 285(4), 1667-1677. doi:10.1006/ jmbi.1998.2395

1998 59.

Couturier, M., Bahassi, E. M., & Van Melderen, L. (1998, juillet). Bacterial death by DNA gyrase poisoning. Trends in microbiology, 6(7), 269-275.

60.

Hilliard, J. J., Simon, L. D., Van Melderen, L., & Maurizi, M. R. (1998, janvier). PinA inhibits ATP hydrolysis and energy-dependent protein degradation by Lon protease. The Journal of biological chemistry, 273(1), 524-527.

1996 61.

Van Melderen, L., Thi, M. H., Lecchi, P., Gottesman, S., Couturier, M., & Maurizi, M. R. (1996, novembre). ATP-dependent degradation of CcdA by Lon protease. Effects of secondary structure and heterologous subunit interactions. The Journal of biological chemistry, 271(44), 27730-27738. doi:10.1074/jbc.271.44.27730

1995 62.

Bahassi, E. M., Salmon, M. A., Van Melderen, L., Bernard, P., & Couturier, M. (1995, mars). F plasmid CcdB killer protein: ccdB gene mutants coding for non-cytotoxic proteins which retain their regulatory functions. Molecular microbiology, 15(6), 1031-1037.

1994 63.

Salmon, M., Van Melderen, L., Bernard, P., & Couturier, M. (1994, septembre). The antidote and autoregulatory functions of the F plasmid CcdA protein: a genetic and biochemical survey. Molecular & general genetics : MGG, 244(5), 530-538.

64.

Van Melderen, L., Bernard, P., & Couturier, M. (1994, mars). Lon-dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid-free segregant bacteria. Molecular microbiology, 11(6), 1151-1157. doi:10.1111/j.1365-2958.1994.tb00391.x

1993 65.

Bernard, P., Kézdy, K. E., Van Melderen, L., Steyaert, J., Wyns, L., Pato, M. L., Higgins, P. N., & Couturier, M. (1993, décembre). The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase. Journal of Molecular Biology, 234(3), 534-541. doi:10.1006/jmbi.1993.1609

66.

Steyaert, J., Van Melderen, L., Bernard, P., Thi, M. H., Loris, R., Wyns, L., & Couturier, M. (1993, mai). Purification, circular dichroism analysis, crystallization and preliminary X-

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ray diffraction analysis of the F plasmid CcdB killer protein. Journal of Molecular Biology, 231(2), 513-515. doi:10.1006/jmbi.1993.1301

5.2.7. - Autres (collaborations nationales et internationales, dépôt de brevets, etc.) 2014 1.

Van Melderen, L., Dumont, B., Hallaert, T., & Vanwalleghem, G. (2014, juillet 04). Method and system for the production of recombinant proteins by cells.

2011 2.

Van Melderen, L., Vanwalleghem, G., et al. (2011, avril 13). BIOLOGICAL GLUE AND METHOD FOR OBTAINING A BIOLOGICAL GLUE.

3.

Van Melderen, L., & Timmermans, J. (2011, avril 06). A method to increase RNA stability.

4.

Dreze, P., Demazy, L., Smeesters, P., & Van Melderen, L. (2011). Streptococcus pneumoniae detection in blood.

2010 5.

Van Melderen, L., & Timmermans, J. (2010, mai 20). Hyperproliferative recombinant cell.

2001 6.

Szpirer, C., Van Melderen, L., & Gabant, P. (2001, février 23). Method for the selection of recombinant clones comprising a sequence encoding an antidote protein to a toxic molecule.

Thèses et mémoires 1995 1.

Van Melderen, L. (1995). Analyse du rôle régulateur de la protéase Lon dans l'activation du système ccd de mort programmée bactérienne (Thèse doctorale non-publiée). Université libre de Bruxelles, Faculté des sciences, Bruxelles.

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