Frank YATES, PhD Human Embryonic Stem Cell Core Facility Hopital Paul Brousse, INSERM U602 Batiment Lavoisier 12 av Paul Vaillant Couturier 94807 VILLEJUIF, FRANCE France : (33) 1 45 59 52 70 RESEARCH EXPERIENCE Mar 2007- Present
Jan 2004-Mar 2007
Research Fellow, INSERM U602 (Human Embryonic Stem Cells Core Facility) Models of genetic disorders in human embryonic stem cells. Supervisor : Pr Annelise Bennaceur-Griscelli Post-Doctoral Research, Children’s Hospital, Boston, MA. Since Jan 2004. Study of the differentiation of murine ES cells into Hematopoietic Stem Cells. Study of the clonogenicity of human ES cells. Supervisor : Pr. George Q. Daley.
Jan 1999 – Dec 2003
Doctoral Research, Necker Children’s Hospital, Paris. Development of a gene therapy protocol in a pre-clinical setting : Gene therapy of RAG1 and RAG2 severe combined immunodeficiencies in a mouse model. Advisor : Pr. Marina Cavazzana-Calvo, INSERM U429, Necker Hospital, Paris, France
Summer 1998
Student Researcher. CEA/Saint-Louis Hospital, Paris. Study of a novel cycline molecule : CDK10/PISSLRE. Advisor : Dr Jean-Yves Thuret, CEA
EDUCATION Dec 2003
Ph.D., Immunology, Necker Children’s Hospital – René Descartes (Paris V) University, Paris, France. Dissertation : Evaluation of the immune system after RAG1/RAG2 gene transfer to hematopoietic stem cells in a murine model. Advisor : Pr. Marina Cavazzana-Calvo
1998
Maîtrise de Sciences : Pierre et Marie Curie (Paris VI) University, Paris. Subject : Cellular and Molecular Genetics.
PUBLICATIONS
Chan EM*, Yates F*, Boyer LF, Schlaeger TM, Daley GQ. Enhanced Plating Efficiency of Trypsin-Adapted Human Embryonic Stem Cells is Reversible and Independent of Trisomy 12/17. *: Equal participation Cloning Stem Cells. 2008 Feb 3 Lengerke C, McKinney-Freeman S, Naveiras O, Yates F, Wang Y, Bansal D, Daley GQ. The Cdx-Hox pathway in hematopoietic stem cell formation from embryonic stem cells. Ann N Y Acad Sci. 2007 Feb 15 Wang Y., Yates F., Naveiras O., and Daley G.Q. (2005). Embryonic stem cell derived hematopoietic stem cells. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19081-6 Yates, F., Malassis-Seris, M., Stockholm, D., Bouneaud, C., Larousserie, F., Noguiez-Hellin, P., Danos, O., Kohn, D. B., Fischer, A., de Villartay, J. P., and Cavazzana-Calvo, M. (2002). Gene therapy of RAG-2-/- mice: sustained correction of the immunodeficiency Blood 100, 3942-9. Lagresle-Peyrou C, Yates F, Malassis-Seris M, Hue C, Morillon E, Garrigue A, Liu A, Hajdari P, Stockholm D, Danos O, Lemercier B, Gougeon ML, Rieux-Laucat F, de Villartay JP, Fischer A, Cavazzana-Calvo M. Long term immune reconstitution in RAG-1 deficient mice treated
by retroviral gene therapy: a balance between efficiency and toxicity. Blood. 2005, Sep 20
Andre-Schmutz I, Bonhomme D, Yates F, Malassis M, Selz F, Fischer A, Cavazzana-Calvo M.
IL-7 effect on immunological reconstitution after HSCT depends on MHC incompatibility. Br J Haematol. 2004 Sep;126(6):844-51
Hacein-Bey, S., Yates, F., de Villartay, J. P., Fischer, A., and Cavazzana-Calvo, M. (2002). Gene
therapy of severe combined immunodeficiencies: from mice to humans Neth J Med 60, 299-301.
Cavazzana-Calvo, M., Hacein-Bey, S., Yates, F., de Villartay, J. P., Le Deist, F., and Fischer, A. (2001). Gene therapy of severe combined immunodeficiencies,
J Gene Med 3, 201-6.
Extracurricular activities Participation to the International Society for Stem Cell Research educational committee Active participation in the organization of seminars intended to bring together PhD students and Biotech Companies : Biotechno Forums 2002 and 2003. Participation to the “National Science Day” in Paris, France. October 2001 Creation of the Necker Institute Student Researcher’s Association. March 2001
