Efficacy of atenolol as a single antihypertensive agent in
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Journal of Feline Medicine and Surgery (2008) 10, 577e582 doi:10.1016/j.jfms.2007.11.008
Efficacy of atenolol as a single antihypertensive agent in hyperthyroid cats Rosemary A Henik DVM, MS, DACVIM (Internal Medicine)1*, Rebecca L Stepien 1 1 2 (Cardiology) , Lisa J Wenholz BS, CVT , Michele K Dolson CVT 1
Department of Medical Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, United States 2 Veterinary Medical Teaching Hospital, University of WisconsinMadison School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, United States
Date accepted: 7 November 2007
b-Adrenergic blockers, particularly atenolol, are often recommended for the tachycardia and hypertension that accompany hyperthyroidism; however, the effects of monotherapy with atenolol on both systolic blood pressure (SBP) and heart rate (HR) have not been reported. Twenty hyperthyroid cats with SBP 160 mmHg were studied retrospectively to investigate the SBP and HR lowering effects of atenolol. Median pre-treatment SBP and HR for all cats were 186.5 mmHg and 231 beats/min, respectively. All cats were treated with atenolol at a dosage of 1e2 mg/kg PO q 12 h for a minimum of 5 days prior to reassessment and treatment with radioactive iodine. SBP and HR both decreased following atenolol therapy in this group of cats to median values of 171.5 mmHg (P ¼ 0.0088) and 185/min (P ¼ 0.0003). However, when successful clinical control of hypertension was defined as a post-treatment SBP
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