Biomarkers in humans: From diagnostic to therapy evaluation tools. â Dubois ... Percentage of success after the first test in humans ... â¢Plus de 1 000 000 000â¬.
Médecine translationnelle et stratégies d'évaluation de médicaments de la cible à l'homme: Exemple de la maladie d'Alzheimer Marc Dhenain URA CEA CNRS 2210 – MIRCen - Fontenay aux Roses Eq. Maladie d'Alzheimer : Modélisation, Biomarqueurs, Imageries Précliniques http://mamobipet.free.fr/Teaching/Teaching.html Translational Research in Neurological Diseases, M. Dhenain - May 2013
Overview Overview on neurodegenerative diseases Strategies for the discovery of new therapies From phenotypic to target based approaches Biomarkers, POM, POC Use of animal model: Target models, predictive models, and biomarkers
Biomarkers in humans: From diagnostic to therapy evaluation tools
Animal models of Alzheimer's disease Most used models of AD Can we predict clinical efficacy of a drug with these models ? ¾ "Classical view" of translational medicine ¾ Translational bridges
Conclusion Translational Research in Neurological Diseases, M. Dhenain - May 2013
Neurodegenerative diseases Disease
Anatomy
Alzheimer
cortex
Parkinson
subst. nigra
80 000
Huntington
striatum
6 000
Spino-cereb. ataxia
cerebellum
Amyotrophic Lat. Scler. cortex, medulla Multiple Sclerosis
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