CV (.pdf) - Alice Lebreton-Mansuy .fr

Intern, Microbiology Institute (Th. Leisinger), ETH Zürich. Grant from the Erasmus exchange program. Transformation of isopropylamine to L-alaninol by ...
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Alice Lebreton Mansuy Group leader in cellular microbiology, INRA Research Scientist

Group Bacterial Infection & RNA Destiny Institute of Biology of École normale supérieure (IBENS) UMR CNRS 8197, Inserm 1024 46, rue d’Ulm F – 75 005 Paris Tel : +33 1 44 32 34 62 e-mail : http://www.biologie.ens.fr/ida

Nationality : French, Swiss Languages : French native speaker, fluent English, school-level Spanish http://alicelebreton.free.fr

Scientific career Since 2015

2008-2014 2006-2008

2002-2006

2000

1999

Group leader at the Institute of Biology of École normale supérieure, Paris. Funding from FRM, ATIP-Avenir, Mairie de Paris, MemoLife. Regulation of host gene expression in response to infection by intracellular bacteria. INRA Research scientist (CR1), UIBC (P. Cossart), Pasteur Institute, Paris. Chromatin subversion & regulation of host gene expression by Listeria monocytogenes. Post-doctoral fellow, Centre de Génétique Moléculaire (B. Séraphin), CNRS, Gif-sur-Yvette. Grant from the French National Research Agency – ANR. RNA exosome activity and nuclear RNA quality control in eukaryotes. Graduate student, GIM (A. Jacquier), Pasteur Institute, Paris. Grants from the French Research Ministry and from ARC Foundation for Cancer Research. Dynamics of ribosome biogenesis in the yeast S. cerevisiae. Intern, Microbiology Institute (Th. Leisinger), ETH Zürich. Grant from the Erasmus exchange program. Transformation of isopropylamine to L-alaninol by Pseudomonas. Summer intern, La Pitié-Salpêtrière hospital, Paris. Histology of a murine model for Parkinson Disease.

Education 2015 2010 2002-2006 1998-2002

Habilitation to supervise research (HDR). Licence for experimentation on mammalian organisms (Nantes Veterinary School). PhD in Microbiology-Virology, Paris 7 University. Undergraduate studies in Biochemistry and Cell Biology at École normale supérieure de Cachan : – 2nd year of Master’s degree in Microbiology-Virology, Paris 7 University/Pasteur Institute, – Agrégation (French degree for high-school teaching) in Biochemistry – Biological Engineering, – Bachelor and 1st year of Master’s degree in Biochemistry and Cell Biology, Paris 7 University.

Supervision Since 2015

2003-2013

Head of a research group at IBENS. Supervision of three post-doctoral fellows, eight students (two rotation students, five Master’s degree and three undergraduates), a bio-informatician engineer and a technician. Co-supervision of a PhD student. Regular hosting of undergraduate students for theoretical or practical mini-projects. Co-supervision of a research engineer and a bio-informatician. Supervision of an assistant-engineer and three Bachelor’s degree summer students.

Teaching Since 2015 Since 2014 Since 2011 2005, 2006 2002-2005

Co-organisation of the Microbial Systems course, IMaLiS, École normale supérieure (Master’s degree). Organisation of the Molecular Cell Biology course for non-biologist students at ENS (Bachelor’s degree). Lecturer at ENS Paris-Saclay, Cell Biology of Host-Invasive Bacteria Interactions course (Master’s degree). Occasional lecturer for Pasteur Institute course of General Microbiology (Master’s degree). Teaching assistant in Immunology (Bachelor’s degree), Paris 7 University. 1

Alice Lebreton Mansuy

CV 2017

Expertise Keynote speaker for Listeria monocytogenes symposium (VetSuisse, Bern, 2014). Invited speaker for RNA & Infection (Würzburg, 2016). Member in three PhD thesis committees. Jury member for PhD and Master’s degree thesis defences. Ad hoc expert for grant proposals and peer-reviewer for scientific journals. Since 2017 Member of the scientific council of the Microbiology department of INRA. Since 2014 Jury member for Complexité du Vivant doctoral school (Paris 6 University) 2013-2014 Member of the Pasteur Institute committee for ethics in animal experimentation.

Organization of scientific events and associative activities Broad audience: Participation in a science/society debate at Institut Henri Poincaré movie-club Univers Convergents (2017). Conferences for ENS open night (2016) and for high-school students (2014) on cell piracy by Listeria monocytogenes. Hosting of secondary school students for laboratory discovery weeks. Secretary and board member of the StaPa association (Pasteur Institute young researchers) (2004-2005). Co-organizer of scientific seminars and of the Pasteur Institute young researchers meeting. Co-organizer of three department and team retreats. Member of the web team of IBENS.

Publications Research articles 1. Lakisic G, Lebreton A*, Pourpre R*, Wendling O, Libertini E, Radford EJ, Le Guillou M, Champy MF, WattenhoferDonzé M, Soubigou G, Ait-Si-Ali S, Feunteun J, Sorg T, Coppée JY, Ferguson-Smith AC, Cossart P & Bierne H. Role of the BAHD1 chromatin-repressive complex in placental development and regulation of steroid metabolism. PLoS Genet. (2016) 12(3):e1005898. 2. Libertini E, Lebreton A, Lakisic G, Dillies M-A, Beck S, Coppée J-Y, Cossart P & Bierne H. Overexpression of the heterochromatinization factor BAHD1 in HEK293 cells differentially reshapes the DNA methylome on autosomes and X chromosome. Front Genet. (2015) 6:339. 3. Lebreton A*, Job V*, Ragon M, Le Monnier A, Dessen A, Cossart P & Bierne H. Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA. mBio (2014) 5(1):e00775-13. 4. Archambaud C, Sismeiro O, Toedling J, Soubigou G, Bécavin C, Lechat P, Lebreton A, Ciaudo C & Cossart P. The intestinal microbiota interferes with the microRNA response upon oral Listeria infection. mBio (2013) 4(6):e00707-13. 5. Gudipati RK, Xu Z, Lebreton A, Séraphin B, Steinmetz LM, Jacquier A & Libri D. Extensive degradation of RNA precursors by the exosome in wild type cells. Mol Cell (2012) 48(3):409-21. 6. Bierne H, Travier L, Mahlakõiv T, Tailleux L, Subtil A, Lebreton A, Paliwal A, Gicquel B, Staeheli P, Lecuit M & Cossart P. Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta. PLoS One (2012) 7(6):e39080. 7. Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï P-J, Regnault B, Nahori M-A, Cabanes D, Gautreau, A, Ait-Si-Ali S, Dessen A, Cossart P & Bierne H. A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science (2011) 331(6022):1319-21. 8. Lebreton A*, Rafal T*, Dziembowski A & Séraphin B. Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature (2008) 456(7224):993-7. 9. Lebreton A, Rousselle J-C, Lenormand P, Namane A, Jacquier A, Fromont-Racine M & Saveanu C. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Nucleic Acids Res. (2008) 36(15):4988-4999. 10. Pertschy B, Saveanu C, Zisser G, Lebreton A, Tengg M, Jacquier A, Liebminger E, Nobis B, Kappel L, van der Klei I, Högenauer G, Fromont-Racine M & Bergler H. Cytoplasmic recycling of 60S pre-ribosomal factors depends on the AAA-protein Drg1. Mol Cell Biol. (2007) 27(19):6581-92. 11. Lebreton A, Saveanu C, Decourty L, Jacquier A & Fromont-Racine M. Nsa2, an unstable, conserved factor required for the maturation of 27SB pre-rRNAs. J Biol Chem. (2006) 281(37):27099-108. 12. Lebreton A, Saveanu C, Decourty L, Rain J-C, Jacquier A & Fromont-Racine M. A functional network involved in the recycling of nucleo-cytoplasmic pre-60S factors. J Cell Biol. (2006) 173(3):349-60. 13. Saveanu C, Namane A, Gleizes P-E, Lebreton A, Rousselle J-C, Noaillac-Depeyre J, Gas N, Jacquier A & FromontRacine M. Sequencial protein association with nascent 60S ribosomal particles. Mol Cell Biol. (2003) 23(13):4449-60.

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Alice Lebreton Mansuy

CV 2017

14. De Azevedo Wäsch SI, van der Ploeg JR, Maire T, Lebreton A, Kiener A & Leisinger T. Transformation of Isopropylamine to L-Alaninol by Pseudomonas sp. Strain KIE171 Involves N-Glutamylated intermediates. Appl Environ Microbiol. (2002) 68(5):2368-75. * Equal contribution.

Reviews and synthesis 15. Lebreton A‡ & Cossart P‡. RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression. RNA Biol. (2017) 14(5):460-70. 16. Duval M, Cossart P‡ & Lebreton A‡. Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk. Semin Cell Dev Biol. 2017) 65:11-19. 17. Lebreton A*, Stavru F*, Brisse S & Cossart P. 1926-2016: 90 years of listeriology. Microbes Infect. (2016) 18(12):71123. 18. Lebreton A, Stavru F & Cossart P. Organelle targeting during bacterial infections: Lessons from Listeria. Trends Cell Biol. (2015) 25(6):330-338. 19. Cossart P‡ & Lebreton A‡. A trip in the “New Microbiology” with the bacterial pathogen Listeria monocytogenes. FEBS Lett. (2014) 588(15):2437-2445. 20. Lebreton A, Cossart P & Bierne H. Bacteria tune interferon responses by playing with chromatin. Virulence (2012) 3(1):1319-21. 21. Lebreton A & Séraphin B. Exosome-mediated quality control: substrate recruitment and molecular activity. Biochim Biophys Acta (2008) 1779(9):558-65. 22. Lebreton A. Dynamique des facteurs pré-ribosomiques au cours de la biogenèse de la grande sous-unité ribosomique chez S. cerevisiae. (2006) Thesis manuscript. ‡ Corresponding authors.

Broad audience publications 23. Lebreton A, Bierne H & Cossart, P. Les multiples stratégies de Listeria. Pour la Science (2012) (412):42-9. 24. Lebreton A. La mise en évidence du bacille de la peste par A. Yersin, Hong-Kong 1894. bibnum (2009). 25. Lebreton A. La génétique et les lois de l’hérédité. Encyclopédie Clartés (2004) 6020:1-22.

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