C57BL/6J Mice JAX® Mice Strain Nomenclature C57BL/6J (inbred)
Strain origin The C57BL/6J inbred strain was created by Dr. C.C. Little: in1921 from the mating of female 57 with male 52 from Miss Abbie Lathrop’s stock. C57BL/6 is the most widely used inbred strain. It was introduced to The Jackson Laboratory in 1948. The colony was transferred to Charles River Laboratories from The Jackson Laboratory in 1981 under the terms of the collaboration agreement between The Jackson Laboratory and Charles River Laboratories. Pedigreed animals were replaced in 1986 and 2003 in accordance with The Jackson Laboratory genetic management guidelines.
MHC haplotype H2b
Appearance Black
Strain characteristics Detailed strain characteristics of the C57BL/6J are available at the website of The Jackson Laboratory: www.jax.org/jaxmice
Research applications • Cardiovascular research Diet-induced atherosclerosis (susceptible) • Developmental biology research Eye Defects Lymphoid Tissue Defects (hematopoietic defects) Skeletal Defects • Diabetes and Obesity research Hyperglycemia (diet-induced, moderate) Hyperinsulinemia (diet-induced) Insulin Resistance (diet-induced) Obesity with Diabetes (diet-induced, moderate) Type 2 Diabetes (NIDDM) (diet-induced) • Hematological research Hematopoietic defects • Immunology and inflammation research Lymphoid tissue defects (hematopoietic development) • Neurobiology research Behavioral and learning defects Vestibular and hearing defects (Age related hearing loss) • Sensorineural research Eye defects Vestibular and hearing defects (Age related hearing loss) • Research tools General Purpose Genetics Research (Mutagenesis and Transgenesis: Production of Transgenic Mice) Hematological research Immunology and Inflammation Research (background strain for histocompatibility congenics)
JAX® Mice1 stock Number 000664 For more information contact us at JAX® is a registered trademark of The Jackson Laboratory. All rights reserved. THESE INBRED MICE SHOULD NOT BE USED FOR FURTHER PROPAGATION OF THE STRAIN. 1
[email protected]
C57BL/6J Mice JAX® Mice Strain Growth Curve 28 27 26 25 24
MEAN VALUES FOR GUIDANCE ONLY
23 22
Male
21 20 19 18 17
Female
16 15 14 13 12 11
WEIGHT IN GRAMS
10 9 8 7 6 5
n = 20 Date = 2005 Breeding Unit = B7, France
4 3 2 1 0
3
4
5
6
7
8
9
10
AGE IN WEEKS Data show mean value +/- 1,96 standard deviation Growth curves may vary slightly from room to room
Breeding system Mating system Litter size at birth Gestation period Weaning age Watering system
Harem - 1 male and 5 females 6-7 19 - 20 days 21 days Filtered (0.1 µm) and UV treatment. Bottle system.
Bedding
Sawdust bedding, autoclaved
Diet
Rodent VRF1, autoclaved, ad libitum
Room temperature
21 +/- 3°C
Light cycle
12-12 (6.00 pm-6.00 am)
Contact Us
[email protected]
www.criver.com
