Application of a Laser Diode Thermal Desorption (LDTD) Ion
Methods. â LDTD: Laser-induced thermal desorption coupled with atmospheric pressure chemical ionization (APCI) on a triple quadrupole mass spectrometer.
Application of a Laser Diode Thermal Desorption (LDTD) Ion Source for Mass Spectrometry in a Drug Discovery Environment Kevin P. Bateman,1 Jin Wu,1 Sebastien Gagne,1 Pierre Picard,2 and Sylvain Letarte2
Frosst Center for Therapeutic Research, Kirkland, QC, Canada; 2Phytronix Technologies Inc., Quebec, QC, Canada Figure 4. Sensitivity, Linearity and Reproducibility
10-plate sample loader
LDTD-MS vs. LC-MS CYP Isoform
– To demonstrate a new laser diode thermal desorption (LDTD) ion source for rapid sample analysis with minimal sample preparation
• Methods – LDTD: Laser-induced thermal desorption coupled with atmospheric pressure chemical ionization (APCI) on a triple quadrupole mass spectrometer – Samples: plasma samples from pharmacokinetic (PK) studies, incubations from cytochrome P450 (CYP) inhibition assays, and phospholipids
• Compound spiked in protein-precipitated plasma supernatant • Triplicate analysis, 2 µL of sample/well (0.26 – 4000 nM), dried • Linear over 3.5 orders of magnitude • LOD ~1 nM, LOQ ~5 nM
• Results Low nM sensitivity for many compounds Dynamic range: 3-4 orders of magnitude; good reproducibility LDTD-APCI-MS/MS works well for a wide range of in vitro/in vivo samples One 96-well plate analyzed in
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